Human IL36RN protein (Recombinant) (N-His) (STJP006707)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human IL36RN-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | IL36RN |
| Gene ID | 26525 |
| Uniprot ID | I36RA_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Lys12-Phe151 |
Additional Info
| Function | Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response.similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR. |
| Protein Name | Interleukin-36 Receptor Antagonist ProteinIl-36raFil1 DeltaIl-1-Related Protein 3Il-1rp3Interleukin-1 Hy1Il-1hy1Interleukin-1 DeltaIl-1 DeltaInterleukin-1 Family Member 5Il-1f5Interleukin-1 Receptor Antagonist Homolog 1Il-1ra Homolog 1Interleukin-1-Like Protein 1Il-1l1 |
| Database Links | Reactome: R-HSA-9014826 |
| Cellular Localisation | CytoplasmSecretedThe Secretion Is Dependent On Protein Unfolding And Facilitated By The Cargo Receptor Tmed10It Results In Protein Translocation From The Cytoplasm Into The Ergic (Endoplasmic Reticulum-Golgi Intermediate Compartment) Followed By Vesicle Entry And Secretion |
| Alternative Protein Names | Interleukin-36 Receptor Antagonist Protein proteinIl-36ra proteinFil1 Delta proteinIl-1-Related Protein 3 proteinIl-1rp3 proteinInterleukin-1 Hy1 proteinIl-1hy1 proteinInterleukin-1 Delta proteinIl-1 Delta proteinInterleukin-1 Family Member 5 proteinIl-1f5 proteinInterleukin-1 Receptor Antagonist Homolog 1 proteinIl-1ra Homolog 1 proteinInterleukin-1-Like Protein 1 proteinIl-1l1 proteinIL36RN proteinFIL1D proteinIL1F5 proteinIL1HY1 proteinIL1L1 proteinIL1RP3 proteinUNQ1896 proteinPRO4342 protein |
Information sourced from Uniprot.org