Human IL27RA/WSX1 protein (Recombinant-Active) (C-hFc-His) (STJP012169)
SPECIFICATIONS
HostMammalian Cells
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Active-Human IL27RA/WSX1-C-hFc-His protein was developed from mammalian cells and has a target region of C-hFc-His. For use in research applications. |
| Applications | ELISA/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8ยฐC for one week. Store at-20 to-80ยฐC for twelve months from the date of receipt. |
| Endotoxin | <0.1 EU/Mu g of the protein by the LAL method. |
| Immunoreactivity | Measured by its ability to inhibit IL-27 anti-viral activity using human hepatocellular carcinoma cells (HepG2) infected with encephalomyocarditis (EMC) virus. The ED50 for this effect is 0.75โ4.5 ยตg/mL. |
Target Information
| Gene Symbol | IL27RA |
| Gene ID | 9466 |
| Uniprot ID | I27RA_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Gly34-Lys516 |
Additional Info
| Function | Receptor for IL27. Requires IL6ST/GP130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Acts as a receptor for the neuroprotective peptide humanin as part of a complex with IL6ST/GP130 and CNTFR. Involved in the regulation of Th1-type immune responses. Also appears to be involved in innate defense mechanisms. |
| Protein Name | Interleukin-27 Receptor Subunit AlphaIl-27 Receptor Subunit AlphaIl-27r Subunit AlphaIl-27r-AlphaIl-27raCytokine Receptor Wsx-1Cytokine Receptor-Like 1Type I T-Cell Cytokine ReceptorTccrZcytor1 |
| Database Links | Reactome: R-HSA-8984722Reactome: R-HSA-9020956 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Interleukin-27 Receptor Subunit Alpha proteinIl-27 Receptor Subunit Alpha proteinIl-27r Subunit Alpha proteinIl-27r-Alpha proteinIl-27ra proteinCytokine Receptor Wsx-1 proteinCytokine Receptor-Like 1 proteinType I T-Cell Cytokine Receptor proteinTccr proteinZcytor1 proteinIL27RA proteinCRL1 proteinTCCR proteinWSX1 proteinUNQ296 proteinPRO336 protein |
Information sourced from Uniprot.org