Human IL24 protein (Recombinant-Active) (C-His) (STJP012089)
SPECIFICATIONS
HostMammalian Cells
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Active-Human IL24-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications. |
| Applications | ELISA/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | <0.1 EU/Mu g of the protein by the LAL method. |
| Immunoreactivity | Measured in a cell proliferation assay using mouse pro-B cells (BaF3) transfected with human IL20 R Alpha and human IL20 R Beta. The EC50 for this effect is typically 0.05-0.25 ng/mL. |
Target Information
| Gene Symbol | IL24 |
| Gene ID | 11009 |
| Uniprot ID | IL24_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Gln53-Leu207 |
Additional Info
| Post Translational Modifications | Glycosylated. Ubiquitination at Lys-122 promotes proteasomal degradation. |
| Function | Multifunctional cytokine mainly produced by T-cells that plays a regulatory role in immune response, tissue homeostasis, host defense, and oncogenesis. Possesses antiviral functions and induces the type I interferon response during influenza infection. Signals through two receptor complexes IL20RA/IL20RB or IL20RB/IL22RA1. In turn, stimulates the JAK1-STAT3 and MAPK pathways and promotes the secretion of pro-inflammatory mediators including IL8 and MMP1. Intracellularly, maintains endoplasmic reticulum homeostasis by restricting the eIF2alpha-CHOP pathway-mediated stress signal. In addition, acts as a quality control mechanism for the ubiquitin proteasome system by alerting the cell to proteasome dysfunction through activation of PKR/EIF2AK2. |
| Protein Name | Interleukin-24Il-24Melanoma Differentiation-Associated Gene 7 ProteinMda-7Suppression Of Tumorigenicity 16 Protein |
| Database Links | Reactome: R-HSA-8854691 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Interleukin-24 proteinIl-24 proteinMelanoma Differentiation-Associated Gene 7 Protein proteinMda-7 proteinSuppression Of Tumorigenicity 16 Protein proteinIL24 proteinMDA7 proteinST16 protein |
Information sourced from Uniprot.org