Human IL22RA2/IL-22BP protein (Recombinant-Active) (C-His) (STJP012223)
SPECIFICATIONS
HostMammalian Cells
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Active-Human IL22RA2/IL-22BP-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications. |
| Applications | ELISA/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | <0.1 EU/Mu g of the protein by the LAL method. |
| Immunoreactivity | Measured by its ability to inhibit IL-22-induced IL-10 secretion by human colorectal adenocarcinoma cells (COLO 205). The ED50 for this effect is typically 1-5 ng/mL in the presence of 1 ng/mL of recombinant human IL-22. |
Target Information
| Gene Symbol | IL22RA2 |
| Gene ID | 116379 |
| Uniprot ID | I22R2_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Thr22-Leu231 |
Additional Info
| Function | Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses. Isoform 1 may play a role in establishing and maintaining successful pregnancy. |
| Protein Name | Interleukin-22 Receptor Subunit Alpha-2Il-22 Receptor Subunit Alpha-2Il-22r-Alpha-2Il-22ra2Cytokine Receptor Class-Ii Member 10Cytokine Receptor Family 2 Member 10Crf2-10Cytokine Receptor Family Type 2 - Soluble 1Crf2-S1Interleukin-22-Binding ProteinIl-22bpIl22bpZcytor16 |
| Database Links | Reactome: R-HSA-8854691 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Interleukin-22 Receptor Subunit Alpha-2 proteinIl-22 Receptor Subunit Alpha-2 proteinIl-22r-Alpha-2 proteinIl-22ra2 proteinCytokine Receptor Class-Ii Member 10 proteinCytokine Receptor Family 2 Member 10 proteinCrf2-10 proteinCytokine Receptor Family Type 2 - Soluble 1 proteinCrf2-S1 proteinInterleukin-22-Binding Protein proteinIl-22bp proteinIl22bp proteinZcytor16 proteinIL22RA2 proteinUNQ5793 proteinPRO19598 proteinPRO19822 protein |
Information sourced from Uniprot.org