Human IL22 (Interleukin-22) Sandwich ELISA Kit (STJE0000025)
SPECIFICATIONS
ConjugationBiotin
General Information
| Short Description | This Interleukin-22 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human serum, plasma and cell culture supernates. |
| Applications | ELISA |
| Reactivity | Human |
| Sensitivity | 15 pg/mL |
| Detection Limit | 312-2000 pg/ml |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Biotin |
| Storage Instruction | Unopened kits can be stored at 2-8°C for 1 year, and opened products must be used within 1 month. |
| Assay Time | 4 hours |
| Detection | Colorimetric |
Target Information
| Gene Symbol | IL22 |
| Gene ID | 50616 |
| Uniprot ID | IL22_HUMAN |
| Sample Type | serum, plasma and cell culture supernates |
Additional Info
| Tissue Specificity | |
| Post Translational Modifications | |
| Function | Cytokine that plays a critical role in modulating tissue responses during inflammation. Plays an essential role in the regeneration of epithelial cells to maintain barrier function after injury and for the prevention of further tissue damage. Unlike most of the cytokines, has no effect on immune cells. Signals through a heterodimeric receptor composed of two subunits, the specific receptor IL22RA1 which is present on non-immune cells in many organs and the shared subunit IL10RB. Ligation of IL22RA1 with IL22 induces activation of the tyrosine kinases JAK1 and TYK2, which in turn activates STAT3. In turn, promotes cell survival and proliferation through STAT3, ERK1/2 and PI3K/AKT pathways. Promotes phosphorylation of GSK3B at 'Ser-9' and CTTN. Promotes epithelial cell spreading. |
| Protein Name | Interleukin-22Il-22Cytokine Zcyto18Il-10-Related T-Cell-Derived-Inducible FactorIl-Tif |
| Database Links | Reactome: R-HSA-8854691Reactome: R-HSA-9725370 |
| Cellular Localisation | Secreted |
| Alternative ELISA Names | Interleukin-22 ELISA kitIl-22 ELISA kitCytokine Zcyto18 ELISA kitIl-10-Related T-Cell-Derived-Inducible Factor ELISA kitIl-Tif ELISA kitIL22 ELISA kitILTIF ELISA kitZCYTO18 ELISA kitUNQ3099 ELISA kitPRO10096 ELISA kit |
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Information sourced from Uniprot.org