Human IL17RD protein (Recombinant) (C-Fc) (STJP013532)
SPECIFICATIONS
HostMammalian Cells
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human IL17RD-C-Fc protein was developed from mammalian cells and has a target region of C-Fc. For use in research applications. |
| Applications | ELISA/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a 0.22 Mu m filtered solution in PBS, pH 7.4. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | < 1 EU/µg as determined by LAL test. |
Target Information
| Gene Symbol | IL17RD |
| Gene ID | 54756 |
| Uniprot ID | I17RD_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Cys17-Arg299 |
Additional Info
| Function | Feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation. Regulates the nuclear ERK signaling pathway by spatially blocking nuclear translocation of activated ERK without inhibiting cytoplasmic phosphorylation of ERK. Mediates JNK activation and may be involved in apoptosis. May inhibit FGF-induced FGFR1 tyrosine phosphorylation. Might have a role in the early stages of fate specification of GnRH-secreting neurons. Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells. |
| Protein Name | Interleukin-17 Receptor DIl-17 Receptor DIl-17rdIl17rhomInterleukin-17 Receptor-Like ProteinSef HomologHsef |
| Database Links | Reactome: R-HSA-5674135 |
| Cellular Localisation | Golgi Apparatus MembraneSingle-Pass Type I Membrane ProteinCell MembranePredominantly Associated With The Golgi Apparatus And Is Partially Translocated To The Plasma Membrane Upon StimulationIsoform 4: Cytoplasm |
| Alternative Protein Names | Interleukin-17 Receptor D proteinIl-17 Receptor D proteinIl-17rd proteinIl17rhom proteinInterleukin-17 Receptor-Like Protein proteinSef Homolog proteinHsef proteinIL17RD proteinIL17RLM proteinSEF proteinUNQ6115 proteinPRO20026 protein |
Information sourced from Uniprot.org