Human IL-5RA/CD125 protein (Recombinant) (C-His) (STJP003097)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human IL-5RA/CD125 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Met1-Glu335) of human IL-5RA/CD125 (Accession #NP_000555.2) fused with and a 6×His tag at the C-terminus.
General Information
| Short Description | Recombinant-Human IL-5RA/CD125-C-His protein was developed in hek293 cells using the region Met1-Glu335. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | < 0.01 EU/Mu g |
Target Information
| Gene Symbol | IL5RA |
| Gene ID | 3568 |
| Uniprot ID | IL5RA_HUMAN |
| Immunogen | Recombinant Human IL-5RA/CD125 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Met1-Glu335) of human IL-5RA/CD125 (Accession #NP_000555.2) fused with and a 6×His tag at the C-terminus. |
| Immunogen Region | Met1-Glu335 |
| Immunogen Sequence | SEIPKGKQKAQLRQREVVDL YNGMCLQGPAGVPGRDGSPG ANGIPGTPGIPGRDGFKGEK GECLRESFEESWTPNYKQCS WSSLNYGIDLGKIAECTFTK MRSNSALRVLFSGSLRLKCR NACCQRWYFTFNGAECSGPL PIEAIIYLDQGSPEMNSTIN IHRTSSVEGLCEGIGAGLVD VAIWVGTCSDYPKGDASTGW NSVSRIIIEELPK |
Additional Info
| Tissue Specificity | Expressed on eosinophils and basophils. |
| Function | Cell surface receptor that plays an important role in the survival, differentiation, and chemotaxis of eosinophils. Acts by forming a heterodimeric receptor with CSF2RB subunit and subsequently binding to interleukin-5. In unstimulated conditions, interacts constitutively with JAK2. Heterodimeric receptor activation leads to JAK2 stimulation and subsequent activation of the JAK-STAT pathway. |
| Protein Name | Interleukin-5 Receptor Subunit AlphaIl-5 Receptor Subunit AlphaIl-5r Subunit AlphaIl-5r-AlphaIl-5raCdw125Cd Antigen Cd125 |
| Database Links | Reactome: R-HSA-512988Reactome: R-HSA-5673001Reactome: R-HSA-912526 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Interleukin-5 Receptor Subunit Alpha proteinIl-5 Receptor Subunit Alpha proteinIl-5r Subunit Alpha proteinIl-5r-Alpha proteinIl-5ra proteinCdw125 proteinCd Antigen Cd125 proteinIL5RA proteinIL5R protein |
Information sourced from Uniprot.org