| Short Description : | Recombinant-Human IL-5 R alpha/CD125-C-His-Avi protein was developed from hek293 and has a target region of C-His-Avi. For use in research applications. |
| Host: | HEK293 |
| Note: | STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Biotin |
| Dilution Range: | Upon receipt centrifuge vial to ensure maximal product extraction, recommended: 20sec, 5K RPM |
| Formulation: | Lyophilised from 0.2 µm filtered PBS solution pH7.4. |
| Storage Instruction: | The lyophilized protein is stable for at least 1 year from date of receipt at-20°C. |
| Endotoxin: | Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg). |
| Gene Symbol: | IL5RA |
| Gene ID: | 3568 |
| Uniprot ID: | IL5RA_HUMAN |
| Immunogen: | DNA sequence encoding Human IL-5 R alpha/CD125 including a C-His-Avi tag was expressed in HEK293 Cells. The recombinant protein was then biotinylated site specific using the AVItag biotinylation technology. |
| Immunogen Region: | Asp21-Glu335 |
| Function | Cell surface receptor that plays an important role in the survival, differentiation, and chemotaxis of eosinophils. Acts by forming a heterodimeric receptor with CSF2RB subunit and subsequently binding to interleukin-5. In unstimulated conditions, interacts constitutively with JAK2. Heterodimeric receptor activation leads to JAK2 stimulation and subsequent activation of the JAK-STAT pathway. |
| Protein Name | Interleukin-5 Receptor Subunit AlphaIl-5 Receptor Subunit AlphaIl-5r Subunit AlphaIl-5r-AlphaIl-5raCdw125Cd Antigen Cd125 |
| Database Links | Reactome: R-HSA-512988Reactome: R-HSA-5673001Reactome: R-HSA-912526 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Interleukin-5 Receptor Subunit Alpha proteinIl-5 Receptor Subunit Alpha proteinIl-5r Subunit Alpha proteinIl-5r-Alpha proteinIl-5ra proteinCdw125 proteinCd Antigen Cd125 proteinIL5RA proteinIL5R protein |
Information sourced from Uniprot.org
