Function | Homodimeric cytokine expressed predominantly by T-lymphocytes and NK cells that plays an important role in the survival, differentiation, and chemotaxis of eosinophils. Acts also on activated and resting B-cells to induce immunoglobulin production, growth, and differentiation. Mechanistically, exerts its biological effects through a receptor composed of IL5RA subunit and the cytokine receptor common subunit beta/CSF2RB. Binding to the receptor leads to activation of various kinases including LYN, SYK and JAK2 and thereby propagates signals through the RAS-MAPK and JAK-STAT5 pathways respectively. |
Protein Name | Interleukin-5Il-5B-Cell Differentiation Factor IEosinophil Differentiation FactorT-Cell Replacing FactorTrf |
Database Links | Reactome: R-HSA-512988Reactome: R-HSA-5673001Reactome: R-HSA-912526 |
Cellular Localisation | Secreted |
Alternative Antibody Pair Names | Interleukin-5 antibody pairIl-5 antibody pairB-Cell Differentiation Factor I antibody pairEosinophil Differentiation Factor antibody pairT-Cell Replacing Factor antibody pairTrf antibody pairIL5 antibody pair |
Information sourced from Uniprot.org