Name: Human IL-3RA/CD123 protein (Recombinant) (C-His) (STJP000897)
SKU: STJP000897
Availability: InStock

Human IL-3RA/CD123 protein (Recombinant) (C-His) (STJP000897)

SKU:

STJP000897

£106.50 - £148.50

Host:	HEK293 cells
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Formulation:	Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method:	< 0.1 EU/Mu g of the protein by LAL method.
Immunoreactivity:	Measured by its binding ability in a functional ELISA. Immobilized recombinant Human IL3 at 4 Mu g/mL (100 Mu L/well) can bind recombinant Human IL3RA, the EC₅₀ of Human IL3RA is 5.3 Mu g/mL.

Gene Symbol:	IL3RA
Gene ID:	3563
Uniprot ID:	IL3RA_HUMAN
Immunogen:	Recombinant Human IL-3RA/CD123 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Lys20-Arg305) of human IL3RA/CD123 (Accession #NP_002174.1) fused with a 6×His tag at the C-terminus.
Immunogen Sequence:	KEDPNPPITNLRMKAKAQQL TWDLNRNVTDIECVKDADYS MPAVNNSYCQFGAISLCEVT NYTVRVANPPFSTWILFPEN SGKPWAGAENLTCWIHDVDF LSCSWAVGPGAPADVQYDLY LNVANRRQQYECLHYKTDAQ GTRIGCRFDDISRLSSGSQS SHILVRGRSAAFGIPCTDKF VVFSQIEILTPPNMTAKCNK THSFMHWKMRSHFNRKFRYE LQIQKRMQPVITEQVRDRT

Post Translational Modifications	Ubiquitinated by RNFT2 in response to IL3. Ubiquitination leads ligand-induced degradation by the proteasome.
Function	Cell surface receptor for IL3 expressed on hematopoietic progenitor cells, monocytes and B-lymphocytes that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Ligand stimulation rapidly induces hetrodimerization with IL3RB, phosphorylation and enzyme activity of effector proteins such as JAK2 and PI3K that play a role in signaling cell proliferation and differentiation. Activation of JAK2 leads to STAT5-mediated transcriptional program.
Protein Name	Interleukin-3 Receptor Subunit Alpha Il-3 Receptor Subunit Alpha Il-3r Subunit Alpha Il-3r-Alpha Il-3ra Cd Antigen Cd123
Database Links	Reactome: R-HSA-512988 Reactome: R-HSA-5673001 Reactome: R-HSA-912526
Cellular Localisation	Membrane Single-Pass Type I Membrane Protein
Alternative Protein Names	Interleukin-3 Receptor Subunit Alpha protein Il-3 Receptor Subunit Alpha protein Il-3r Subunit Alpha protein Il-3r-Alpha protein Il-3ra protein Cd Antigen Cd123 protein IL3RA protein IL3R protein

Information sourced from Uniprot.org

Model	Name	Host
STJP001733	Human IL-3 R alpha/CD123 protein (Recombinant) (C-His-Avi) {Biotin} (STJP001733)	HEK293
STJP001313	Human IL-13 protein (Recombinant) (C-His) (STJP001313)	HEK293 cells
STJP002824	Human IL-22 protein (Recombinant) (C-His) (STJP002824)	HEK293 cells
STJP001120	Human IL-7 protein (Recombinant) (C-His) (STJP001120)	HEK293 cells
STJP001306	Human IL-21 protein (Recombinant) (C-His) (STJP001306)	HEK293 cells
STJP000776	Human IL-1RN protein (Recombinant) (C-His) (STJP000776)	E. coli

Human IL-3RA/CD123 protein (Recombinant) (C-His) (STJP000897)