| Host: | E.coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 0.01 EU/Mu g of the protein by LAL method. |
| Gene Symbol: | CSF2RB |
| Gene ID: | 1439 |
| Uniprot ID: | IL3RB_HUMAN |
| Immunogen Region: | Trp17-Trp443 |
| Immunogen: | Recombinant Human IL-3R Beta/CSF2RB/CD131 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Trp17-Trp443 ) of Human IL-3R Beta/CSF2RB/CD131 (Accession #NP_000386.1 fused with a His tag at the C-term |
| Immunogen Sequence: | AELRCMCIKTTSGIHPKNIQ SLEVIGKGTHCNQVEVIATL KDGRKICLDPDAPRIKKIVQ KKLAGDESAD |
| Post Translational Modifications | May be phosphorylated by LYN. |
| Function | Cell surface receptor that plays a role in immune response and controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Acts by forming an heterodimeric receptor through interaction with different partners such as IL3RA, IL5RA or CSF2RA. In turn, participates in various signaling pathways including interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor/CSF2 pathways. In unstimulated conditions, interacts constitutively with JAK1 and ligand binding leads to JAK1 stimulation and subsequent activation of the JAK-STAT pathway. |
| Protein Name | Cytokine Receptor Common Subunit Beta Cdw131 Gm-Csf/Il-3/Il-5 Receptor Common Beta Subunit Cd Antigen Cd131 |
| Database Links | Reactome: R-HSA-512988 Reactome: R-HSA-5673001 Reactome: R-HSA-5683826 Reactome: R-HSA-5688849 Reactome: R-HSA-5688890 Reactome: R-HSA-912526 |
| Cellular Localisation | Membrane Single-Pass Type I Membrane Protein |
| Alternative Protein Names | Cytokine Receptor Common Subunit Beta protein Cdw131 protein Gm-Csf/Il-3/Il-5 Receptor Common Beta Subunit protein Cd Antigen Cd131 protein CSF2RB protein IL3RB protein IL5RB protein |
Information sourced from Uniprot.org
