Human IL-38/IL-1F10 protein (Recombinant) (No-Tag) (STJP019129)

Name: Human IL-38/IL-1F10 protein (Recombinant) (No-Tag) (STJP019129)
SKU: STJP019129
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⇓ Datasheet ⇓ SDS

SPECIFICATIONS

HostE.coli

ImmunogenHuman

STJP019129

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Short Description	Recombinant-Human IL-38/IL-1F10-No-Tag protein was developed from e.coli and has a target region of No-Tag. For use in research applications.
Applications	SDS-PAGE
Host	E.coli
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Concentration	1 mg/mL
Formulation	Liquid in phosphate-Buffered Saline (pH 7.4)
Storage Instruction	For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Endotoxin	< 1 EU per 1ug of protein (determined by LAL method)

Gene Symbol	IL1F10
Gene ID	84639
Uniprot ID	IL1FA_HUMAN
Accession Number	NP_115945.3
Immunogen	Human
Immunogen Region	1-152aa
Immunogen Sequence	MCSLPMARYY IIKYADQKAL YTRDGQLLVG DPVADNCCAE KICTLPNRGL DRTKVPIFLG IQGGSRCLAC VETEEGPSLQ LEDVNIEELY KGGEEATRFT FFQSSSGSAF RLEAAAWPGW FLCGPAEPQQ PVQLTKESEP SARTKFYFEQ SW

Tissue Specificity	Expressed in fetal skin, spleen and tonsil. Expressed mostly in the basal epithelia of skin and in proliferating B-cells of the tonsil.
Function	Cytokine with immunomodulatory activity. Alone, does not induce cytokine production, but reduces IL22 and IL17A production by T-cells in response to heat-killed Candida albicans. Reduces IL36G-induced production of IL8 by peripheral blood mononuclear cells. Increases IL6 production by dendritic cells stimulated by bacterial lipopolysaccharides (LPS). Ligand for IL-36R/IL1RL2.
Protein Name	Interleukin-1 Family Member 10 Il-1f10 Family Of Interleukin 1-Theta Fil1 Theta Interleukin-1 Hy2 Il-1hy2 Interleukin-1 Theta Il-1 Theta Interleukin-38 Il-38
Database Links	Reactome: R-HSA-9007892 Reactome: R-HSA-9014826
Cellular Localisation	Cytoplasm Secreted The Secretion Is Dependent On Protein Unfolding And Facilitated By The Cargo Receptor Tmed10 It Results In Protein Translocation From The Cytoplasm Into The Ergic (Endoplasmic Reticulum-Golgi Intermediate Compartment) Followed By Vesicle Entry And Secretion
Alternative Protein Names	Interleukin-1 Family Member 10 protein Il-1f10 protein Family Of Interleukin 1-Theta protein Fil1 Theta protein Interleukin-1 Hy2 protein Il-1hy2 protein Interleukin-1 Theta protein Il-1 Theta protein Interleukin-38 protein Il-38 protein IL1F10 protein FIL1T protein IL1HY2 protein IL38 protein FKSG75 protein UNQ6119 protein PRO20041 protein

Information sourced from Uniprot.org