Human IL-34 protein (Recombinant) (C-6His) (STJP001893)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant human IL-34 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Asn21-Pro242) of human IL-34 (Accession #NP_689669.2) fused with and a 6×His tag at the C-terminus.
General Information
| Short Description | Recombinant-Human IL-34-C-6His protein was developed in hek293 cells using the region Asn21-Pro242. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | < 0.01 EU/Mu g |
Target Information
| Gene Symbol | IL34 |
| Gene ID | 146433 |
| Uniprot ID | IL34_HUMAN |
| Immunogen | Recombinant human IL-34 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Asn21-Pro242) of human IL-34 (Accession #NP_689669.2) fused with and a 6×His tag at the C-terminus. |
| Immunogen Region | Asn21-Pro242 |
| Immunogen Sequence | NEPLEMWPLTQNEECTVTGF LRDKLQYRSRLQYMKHYFPI NYKISVPYEGVFRIANVTRL QRAQVSERELRYLWVLVSLS ATESVQDVLLEGHPSWKYLQ EVETLLLNVQQGLTDVEVSP KVESVLSLLNAPGPNLKLVR PKALLDNCFRVMELLYCSCC KQSSVLNWQDCEVPSPQSCS PEPSLQYAATQLYPPPPWSP SSPPHSTGSVRPVRAQGEGL LP |
Additional Info
| Function | Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of pro-inflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1. |
| Protein Name | Interleukin-34Il-34 |
| Database Links | Reactome: R-HSA-449836Reactome: R-HSA-9680350 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Interleukin-34 proteinIl-34 proteinIL34 proteinC16orf77 protein |
Information sourced from Uniprot.org