| Short Description : | Recombinant-Human IL-27RA/TCCR-C-hFc protein was developed in hek293 cells using the region Gly34-Lys516. For use in research applications. |
| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 1 EU/Mu g of the protein by LAL method. |
| Gene Symbol: | IL27RA |
| Gene ID: | 9466 |
| Uniprot ID: | I27RA_HUMAN |
| Immunogen: | Recombinant Human IL-27 Ra/TCCR Protein is produced by Expi293 expression system. The target protein is expressed with sequence (Gly34-Lys516) of Human IL-27 Ra/TCCR fused with a hFc tag at the C-terminal. |
| Immunogen Region: | Gly34-Lys516 |
| Immunogen Sequence: | GSAGPLQCYGVGPLGDLNCS WEPLGDLGAPSELHLQSQKY RSNKTQTVAVAAGRSWVAIP REQLTMSDKLLVWGTKAGQP LWPPVFVNLETQMKPNAPRL GPDVDFSEDDPLEATVHWAP PTWPSHKVLICQFHYRRCQE AAWTLLEPELKTIPLTPVEI QDLELATGYKVYGRCRMEKE EDLWGEWSPILSFQTPPSAP KDVWVSGNLCGTPGGEEPLL LWKAPGPCVQVSYKVWFWV |
| Function | Receptor for IL27. Requires IL6ST/GP130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Acts as a receptor for the neuroprotective peptide humanin as part of a complex with IL6ST/GP130 and CNTFR. Involved in the regulation of Th1-type immune responses. Also appears to be involved in innate defense mechanisms. |
| Protein Name | Interleukin-27 Receptor Subunit AlphaIl-27 Receptor Subunit AlphaIl-27r Subunit AlphaIl-27r-AlphaIl-27raCytokine Receptor Wsx-1Cytokine Receptor-Like 1Type I T-Cell Cytokine ReceptorTccrZcytor1 |
| Database Links | Reactome: R-HSA-8984722Reactome: R-HSA-9020956 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Interleukin-27 Receptor Subunit Alpha proteinIl-27 Receptor Subunit Alpha proteinIl-27r Subunit Alpha proteinIl-27r-Alpha proteinIl-27ra proteinCytokine Receptor Wsx-1 proteinCytokine Receptor-Like 1 proteinType I T-Cell Cytokine Receptor proteinTccr proteinZcytor1 proteinIL27RA proteinCRL1 proteinTCCR proteinWSX1 proteinUNQ296 proteinPRO336 protein |
Information sourced from Uniprot.org
