Recombinant Human IL-25/IL-17E Protein was determined by SDS-PAGE with Coomassie Blue, showing a band at 20-30 kDa.

Human IL-25/IL-17E protein (Recombinant) (C-hFc&His) (STJP002998)

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STJP002998
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Host: HEK293 cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Formulation: Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: <0.1 EU/Mu g of the protein by LAL method.
Immunoreactivity: Measured by its ability to induce CXCL1/GRO alpha secretion in HT-29 human colon adenocarcinoma cells. The ED50 for this effect is 5.46-21.84ng/mL, corresponding to a specific activity of 4.58×104~1.83×105 units/mg.
Gene Symbol: IL25
Gene ID: 64806
Uniprot ID: IL25_HUMAN
Immunogen Region: Tyr33-Gly177
Immunogen: Recombinant Human IL-25/IL-17E Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Tyr33-Gly177) of Human IL-25/IL-17E (Accession #NP_073626.1) fused with a His tag at the N-terminus.
Immunogen Sequence: HPLMVSDRMDLDTLARSRQL EKRMSEEMRLLEMEFEERKR AAEQRQKAENFWTGDTSSDQ LVLGKKDMGWPFQADGQEG
Tissue Specificity Expressed at low levels in several tissues, including brain, kidney, lung, prostate, testis, spinal cord, adrenal gland, and trachea.
Function Cytokine produced by various cells such as eosinophils, T-helper type 2 (Th2) cells or epithelial cells that plays a role in internal safety of adaptive immune responses by regulating cytokine production. Promotes and augments T-helper type 2 responses locally or systemically. Exerts its activity via its receptor composed of IL17RA and IL17RB for signal transduction. In turn, stimulates the JAK2-STAT5A pathway and promotes the secretion of type-2 associated cytokines including IL4, IL9 and IL13. Induces also the release of IL8, and IL6 from eosinophils through the combined activation of MAPK and NF-kappa-B pathways. Inhibits the differentiation of T-helper (Th17) cells via the production of IL4, IL5 and IL13.
Protein Name Interleukin-25
Il-25
Interleukin-17e
Il-17e
Database Links Reactome: R-HSA-448424
Cellular Localisation Secreted
Alternative Protein Names Interleukin-25 protein
Il-25 protein
Interleukin-17e protein
Il-17e protein
IL25 protein
IL17E protein
UNQ3120 protein
PRO10272 protein

Information sourced from Uniprot.org

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