Human IL-17E/IL-25 protein (Recombinant) (His-Tag) (STJP019465)
SPECIFICATIONS
HostHEK293 Cells
ImmunogenHuman
General Information
| Short Description | Recombinant-Human IL-17E/IL-25-His-Tag protein was developed from hek293 cells and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE/Bioactivity |
| Host | HEK293 Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid In Phosphate-Buffered Saline (pH 7.4) containing 20% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
| Endotoxin | < 1 EU per 1ug of protein (determined by LAL method) |
| Immunoreactivity | Measured by its binding ability in a functional ELISA with Human IL-17 RB |
Target Information
| Gene Symbol | IL25 |
| Gene ID | 64806 |
| Uniprot ID | IL25_HUMAN |
| Accession Number | NP_073626.1 |
| Immunogen | Human |
| Immunogen Region | 33-177aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Expressed at low levels in several tissues, including brain, kidney, lung, prostate, testis, spinal cord, adrenal gland, and trachea. |
| Function | Cytokine produced by various cells such as eosinophils, T-helper type 2 (Th2) cells or epithelial cells that plays a role in internal safety of adaptive immune responses by regulating cytokine production. Promotes and augments T-helper type 2 responses locally or systemically. Exerts its activity via its receptor composed of IL17RA and IL17RB for signal transduction. In turn, stimulates the JAK2-STAT5A pathway and promotes the secretion of type-2 associated cytokines including IL4, IL9 and IL13. Also induces the release of IL8, and IL6 from eosinophils through the combined activation of MAPK and NF-kappa-B pathways. Inhibits the differentiation of T-helper (Th17) cells via the production of IL4, IL5 and IL13. |
| Protein Name | Interleukin-25Il-25Interleukin-17eIl-17e |
| Database Links | Reactome: R-HSA-448424 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Interleukin-25 proteinIl-25 proteinInterleukin-17e proteinIl-17e proteinIL25 proteinIL17E proteinUNQ3120 proteinPRO10272 protein |
Information sourced from Uniprot.org