| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | <1 EU/Mu g |
| Immunoreactivity: | Measured by its binding ability in a functional ELISA.Immobilized Human IL-12B&IL-23A at 5 Mu g/mL (100 Mu L/well) can bind Human IL23R with a linear range of 4-135 ng/ml. |
| Gene Symbol: | IL23R |
| Gene ID: | 149233 |
| Uniprot ID: | IL23R_HUMAN |
| Immunogen: | Recombinant Human IL-23R Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gly24-Gly355) of human IL23R (Accession #NP_653302.2) fused with a hFc tag at the C-terminus. |
| Immunogen Sequence: | GITNINCSGHIWVEPATIFK MGMNISIYCQAAIKNCQPRK LHFYKNGIKERFQITRINKT TARLWYKNFLEPHASMYCTA ECPKHFQETLICGKDISSGY PPDIPDEVTCVIYEYSGNMT CTWNAGKLTYIDTKYVVHVK SLETEEEQQYLTSSYINIST DSLQGGKKYLVWVQAANALG MEESKQLQIHLDDIVIPSAA VISRAETINATVPKTIIYWD SQTTIEKVSCEMRYKATTN |
| Post Translational Modifications | Phosphorylated in response to IL23. |
| Function | Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis. |
| Protein Name | Interleukin-23 Receptor Il-23 Receptor Il-23r |
| Database Links | Reactome: R-HSA-6785807 Reactome: R-HSA-9020933 |
| Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein |
| Alternative Protein Names | Interleukin-23 Receptor protein Il-23 Receptor protein Il-23r protein IL23R protein |
Information sourced from Uniprot.org