Human IL-23R protein (Recombinant) (C-hFc) (STJP001369)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human IL-23R Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gly24-Gly355) of human IL23R (Accession #NP_653302.2) fused with a hFc tag at the C-terminus.
General Information
| Short Description | Recombinant-Human IL-23R-C-hFc protein was developed in hek293 cells using the region Gly24-Gly355. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity | Measured by its binding ability in a functional ELISA.Immobilized Human IL-12B&IL-23A at 5 Mu g/mL (100 Mu L/well) can bind Human IL23R with a linear range of 4-135 ng/ml. |
| Determination Method | <1 EU/Mu g |
Target Information
| Gene Symbol | IL23R |
| Gene ID | 149233 |
| Uniprot ID | IL23R_HUMAN |
| Immunogen | Recombinant Human IL-23R Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gly24-Gly355) of human IL23R (Accession #NP_653302.2) fused with a hFc tag at the C-terminus. |
| Immunogen Region | Gly24-Gly355 |
| Immunogen Sequence | GITNINCSGHIWVEPATIFK MGMNISIYCQAAIKNCQPRK LHFYKNGIKERFQITRINKT TARLWYKNFLEPHASMYCTA ECPKHFQETLICGKDISSGY PPDIPDEVTCVIYEYSGNMT CTWNAGKLTYIDTKYVVHVK SLETEEEQQYLTSSYINIST DSLQGGKKYLVWVQAANALG MEESKQLQIHLDDIVIPSAA VISRAETINATVPKTIIYWD SQTTIEKVSCEMRYKATTN |
Additional Info
| Post Translational Modifications | Phosphorylated in response to IL23. |
| Function | Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis. |
| Protein Name | Interleukin-23 ReceptorIl-23 ReceptorIl-23r |
| Database Links | Reactome: R-HSA-6785807Reactome: R-HSA-9020933 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Interleukin-23 Receptor proteinIl-23 Receptor proteinIl-23r proteinIL23R protein |
Information sourced from Uniprot.org