| Short Description : | Recombinant-Human IL-23A&Mouse IL-12B-C-His&Avi protein was developed in hek293 cells using the region Arg20-Pro189. For use in research applications. |
| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Formulation: | Lyophilised from 0.22 Mu m filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 1 EU/Mu g of the protein by LAL method. |
| Immunogen: | Recombinant Human IL-23A&Mouse IL-12B Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Arg20-Pro189 (Human IL-23 alpha) & Met23-Ser335 (Mouse IL-12 beta) ) of Human IL-23 alpha&Mouse IL-12 beta (Ac |
| Immunogen Region: | Arg20-Pro189 |
| Immunogen Sequence: | RAVPGGSSPAWTQCQQLSQK LCTLAWSAHPLVGHMDLREE GDEETTNDVPHIQCGDGCDP QGLRDNSQFCLQRIHQGLIF YEKLLGSDIFTGEPSLLPDS PVGQLHASLLGLSQLLQPEG HHWETQQIPSLSPSQPWQRL LLRFKILRSLQAFVAVAARV FAHGAATLSPMWELEKDVYV VEVDWTPDAPGETVNLTCDT PEEDDITWTSDQRHGVIGSG KTLTITVKEFLDAGQYTCH |
| Background | Interleukin (IL)-12 and IL-23 belong to the IL-12 type family and are composite cytokines, consisting of the common Beta subunit p40 and the specific cytokine Alpha subunit p35 and p19, respectively. IL-12 signals via the IL-12R Beta 1·IL-12R Beta 2 receptor complex, and IL-23 uses also IL-12R Beta 1 but engages IL-23R as second receptor. |
Information sourced from Uniprot.org
