Human IL-23/IL-12B&IL-23A protein (Recombinant) (C-His&Avi) {Biotin} (STJP020038)
SPECIFICATIONS
HostHEK293 cells
ConjugationBiotin
ImmunogenBiotinylated Recombinant Human IL-23/IL-12B&IL-23A Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Arg20-Pro189 (IL-23 alpha) & Ile23-Ser328 (IL-12 beta) ) of Human IL-23 alpha&IL-12 beta (Accessi
General Information
| Short Description | Recombinant-Human IL-23/IL-12B&IL-23A-C-His&Avi protein was developed in hek293 cells using the region Arg20-Pro189. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Biotin |
| Formulation | Lyophilised from 0.22 Mu m filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | < 1 EU/Mu g of the protein by LAL method. |
Target Information
| Immunogen | Biotinylated Recombinant Human IL-23/IL-12B&IL-23A Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Arg20-Pro189 (IL-23 alpha) & Ile23-Ser328 (IL-12 beta) ) of Human IL-23 alpha&IL-12 beta (Accessi |
| Immunogen Region | Arg20-Pro189 |
| Immunogen Sequence | RAVPGGSSPAWTQCQQLSQK LCTLAWSAHPLVGHMDLREE GDEETTNDVPHIQCGDGCDP QGLRDNSQFCLQRIHQGLIF YEKLLGSDIFTGEPSLLPDS PVGQLHASLLGLSQLLQPEG HHWETQQIPSLSPSQPWQRL LLRFKILRSLQAFVAVAARV FIWELKKDVYVVELDWYPDA PGEMVVLTCDTPEEDGITWT LDQSSEVLGSGKTLTIQVKE FGDAGQYTCHKGGEVLSHS |
Additional Info
| Background | The interleukin (IL)-12 family of cytokines, including IL12 and IL 23, play an important role in driving aberrant Th1 and Th17 immune responses in patients with Crohn s disease (CD). Targeting this pathway has opened new avenues for therapeutic intervention. The balance of proinflammatory cytokines interleukin (IL)-12 and IL-23 plays a key role in shaping the development of antitumor or protumor immunity. |
Information sourced from Uniprot.org