Host: |
HEK293 cells |
Reactivity: |
Human |
Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: |
Recombinant-Human IL-22RA2/IL22BP-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications. |
Formulation: |
Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation. |
Immunoreactivity: |
Measured by its binding ability in a functional ELISA. Immobilized recombinant Human IL22 at 2 Mu g/mL (100 Mu L/well) can bind recombinant Human IL22BP, the EC50 of Human IL22BP is 10.78 ng/mL. |
Gene Symbol: |
IL22RA2 |
Gene ID: |
116379 |
Uniprot ID: |
I22R2_HUMAN |
Immunogen: |
Recombinant Human IL-22RA2/IL22BP Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Thr22-Pro231) of human IL-22BP/IL-22RA2 (Accession #NP_851826.1) fused with a 6×His tag at the C-terminus. |
Tissue Specificity | Expressed in placenta, spleen, breast, skin and lung. Also detected in intestinal tract, testis, brain, heart and thymus. No expression found in prostate, bladder, kidney, ovary, muscle, bone marrow, liver and uterus. Isoform 1 is expressed only in placenta. Isoform 2 is expressed in placenta and breast and at lower level in spleen, skin, thymus and stomach. |
Function | Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses. Isoform 1 may play a role in establishing and maintaining successful pregnancy. |
Protein Name | Interleukin-22 Receptor Subunit Alpha-2Il-22 Receptor Subunit Alpha-2Il-22r-Alpha-2Il-22ra2Cytokine Receptor Class-Ii Member 10Cytokine Receptor Family 2 Member 10Crf2-10Cytokine Receptor Family Type 2 - Soluble 1Crf2-S1Interleukin-22-Binding ProteinIl-22bpIl22bpZcytor16 |
Database Links | Reactome: R-HSA-8854691 |
Cellular Localisation | Secreted |
Alternative Protein Names | Interleukin-22 Receptor Subunit Alpha-2 proteinIl-22 Receptor Subunit Alpha-2 proteinIl-22r-Alpha-2 proteinIl-22ra2 proteinCytokine Receptor Class-Ii Member 10 proteinCytokine Receptor Family 2 Member 10 proteinCrf2-10 proteinCytokine Receptor Family Type 2 - Soluble 1 proteinCrf2-S1 proteinInterleukin-22-Binding Protein proteinIl-22bp proteinIl22bp proteinZcytor16 proteinIL22RA2 proteinUNQ5793 proteinPRO19598 proteinPRO19822 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance