Human IL-22RA2/IL22BP protein (Recombinant) (C-His) (STJP000965)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human IL-22RA2/IL22BP Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Thr22-Pro231) of human IL-22BP/IL-22RA2 (Accession #NP_851826.1) fused with a 6ΓHis tag at the C-terminus.
General Information
| Short Description | Recombinant-Human IL-22RA2/IL22BP-C-His protein was developed in hek293 cells using the region Thr22-Pro231. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20Β°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity | Measured by its binding ability in a functional ELISA. Immobilized recombinant Human IL22 at 2 Mu g/mL (100 Mu L/well) can bind recombinant Human IL22BP, the EC50 of Human IL22BP is 10.78 ng/mL. |
| Determination Method | < 0.1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | IL22RA2 |
| Gene ID | 116379 |
| Uniprot ID | I22R2_HUMAN |
| Immunogen | Recombinant Human IL-22RA2/IL22BP Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Thr22-Pro231) of human IL-22BP/IL-22RA2 (Accession #NP_851826.1) fused with a 6ΓHis tag at the C-terminus. |
| Immunogen Region | Thr22-Pro231 |
| Immunogen Sequence | TQSTHESLKPQRVQFQSRNF HNILQWQPGRALTGNSSVYF VQYKIYGQRQWKNKEDCWGT QELSCDLTSETSDIQEPYYG RVRAASAGSYSEWSMTPRFT PWWETKIDPPVMNITQVNGS LLVILHAPNLPYRYQKEKNV SIEDYYELLYRVFIINNSLE KEQKVYEGAHRAVEIEALTP HSSYCVVAEIYQPMLDRRSQ RSEERCVEIP |
Additional Info
| Tissue Specificity | Expressed in placenta, spleen, breast, skin and lung. Also detected in intestinal tract, testis, brain, heart and thymus. No expression found in prostate, bladder, kidney, ovary, muscle, bone marrow, liver and uterus. Isoform 1 is expressed only in placenta. Isoform 2 is expressed in placenta and breast and at lower level in spleen, skin, thymus and stomach. |
| Function | Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses. Isoform 1 may play a role in establishing and maintaining successful pregnancy. |
| Protein Name | Interleukin-22 Receptor Subunit Alpha-2Il-22 Receptor Subunit Alpha-2Il-22r-Alpha-2Il-22ra2Cytokine Receptor Class-Ii Member 10Cytokine Receptor Family 2 Member 10Crf2-10Cytokine Receptor Family Type 2 - Soluble 1Crf2-S1Interleukin-22-Binding ProteinIl-22bpIl22bpZcytor16 |
| Database Links | Reactome: R-HSA-8854691 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Interleukin-22 Receptor Subunit Alpha-2 proteinIl-22 Receptor Subunit Alpha-2 proteinIl-22r-Alpha-2 proteinIl-22ra2 proteinCytokine Receptor Class-Ii Member 10 proteinCytokine Receptor Family 2 Member 10 proteinCrf2-10 proteinCytokine Receptor Family Type 2 - Soluble 1 proteinCrf2-S1 proteinInterleukin-22-Binding Protein proteinIl-22bp proteinIl22bp proteinZcytor16 proteinIL22RA2 proteinUNQ5793 proteinPRO19598 proteinPRO19822 protein |
Information sourced from Uniprot.org