Human IL-21 protein (Recombinant) (N-HIS＆AVI) {Biotin} (STJP020383)
SPECIFICATIONS
HostE.coli
ConjugationBiotin
ImmunogenBiotinylated Recombinant Human IL-21 Protein is produced by E. coli expression system. The target protein is expressed with sequence (Gln32-Ser162) of Human IL-21 (NP_068575.1) fused with His tag and Avi tag at the N-Terminus.
General Information
| Short Description | Recombinant-Human IL-21-N-HIS＆AVI protein was developed in e.coli using the region Gln32-Ser162. For use in research applications. |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Biotin |
| Formulation | Lyophilised from 0.22 Mu m filtered solution in 20mM NaAc, 500mM NaCl (pH 5.5). Normally 8% trehalose is added as protectant before lyophilization. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | < 1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | IL21 |
| Gene ID | 59067 |
| Uniprot ID | IL21_HUMAN |
| Immunogen | Biotinylated Recombinant Human IL-21 Protein is produced by E. coli expression system. The target protein is expressed with sequence (Gln32-Ser162) of Human IL-21 (NP_068575.1) fused with His tag and Avi tag at the N-Terminus. |
| Immunogen Region | Gln32-Ser162 |
| Immunogen Sequence | QDRHMIRMRQLIDIVDQLKN YVNDLVPEFLPAPEDVETNC EWSAFSCFQKAQLKSANTGN NERIINVSIKKLKRKPPSTN AGRRQKHRLTCPSCDSYEKK PPKEFLERFKSLLQKMIHQH LSSRTHGSEDS |
Additional Info
| Tissue Specificity | Expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes. |
| Function | Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. Implicated in the generation and maintenance of T follicular helper (Tfh) cells and the formation of germinal-centers. Together with IL6, control the early generation of Tfh cells and are critical for an effective antibody response to acute viral infection. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation. |
| Protein Name | Interleukin-21Il-21Za11 |
| Database Links | Reactome: R-HSA-9020958 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Interleukin-21 proteinIl-21 proteinZa11 proteinIL21 protein |
Information sourced from Uniprot.org