Human IL-1R1 (Interleukin-1 Receptor Type 1) Antibody Pair (STJAP00402)
General Information
| Short Description | This IL-1R1 antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA. |
| Applications | ELISA |
| Host | Goat/Goat |
| Reactivity | Human |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated/Biotin |
| Concentration | 0.5 mg/mL |
| Purification | Capture Purification: Antigen Affinity.Detection Purification: Antigen Affinity. |
| Formulation | Capture Buffer: PBS with 0.04% Proclin 300; 50% glycerol; pH 7.5.Detection Buffer: PBS with 0.04% Proclin 300; 1% protective protein; 50% glycerol; pH 7.5. |
| Storage Instruction | Store at-20°C for the long term, and avoid freeze-thaw cycles. |
| Determination Method | Colormetric |
Target Information
| Gene Symbol | IL1R1 |
| Gene ID | 3554 |
| Uniprot ID | IL1R1_HUMAN |
| Immunogen | Capture immunogen: Recombinant Human IL-1R1 protien.Detection Immunogen: Recombinant Human IL-1R1 protien. |
| Sample Type | Serum, plasma and other biological fluids |
Additional Info
| Post Translational Modifications | A soluble form (sIL1R1) is probably produced by proteolytic cleavage at the cell surface (shedding). Rapidly phosphorylated on Tyr-496 in response to IL-1, which creates a SH2 binding site for the PI 3-kinase regulatory subunit PIK3R1. |
| Function | Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells. |
| Protein Name | Interleukin-1 Receptor Type 1Il-1r-1Il-1rt-1Il-1rt1Cd121 Antigen-Like Family Member AInterleukin-1 Receptor AlphaIl-1r-AlphaInterleukin-1 Receptor Type IP80Cd Antigen Cd121a Cleaved Into - Interleukin-1 Receptor Type 1 - Membrane FormMil-1r1Mil-1ri - Interleukin-1 Receptor Type 1 - Soluble FormSil-1r1Sil-1ri |
| Database Links | Reactome: R-HSA-6783783Reactome: R-HSA-9020702Reactome: R-HSA-9679191 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane ProteinCell MembraneSecreted |
| Alternative Antibody Pair Names | Interleukin-1 Receptor Type 1 antibody pairIl-1r-1 antibody pairIl-1rt-1 antibody pairIl-1rt1 antibody pairCd121 Antigen-Like Family Member A antibody pairInterleukin-1 Receptor Alpha antibody pairIl-1r-Alpha antibody pairInterleukin-1 Receptor Type I antibody pairP80 antibody pairCd Antigen Cd121a Cleaved Into - Interleukin-1 Receptor Type 1 - Membrane Form antibody pairMil-1r1 antibody pairMil-1ri - Interleukin-1 Receptor Type 1 - Soluble Form antibody pairSil-1r1 antibody pairSil-1ri antibody pairIL1R1 antibody pairIL1R antibody pairIL1RA antibody pairIL1RT1 antibody pair |
Information sourced from Uniprot.org
Citations
Product Review
Frequently Asked Questions
Common questions about Human IL-1R1 (Interleukin-1 Receptor Type 1) Antibody Pair (STJAP00402)
This antibody pair detects human Interleukin-1 Receptor Type 1 (IL-1R1, UniProt P14778) and is validated for human samples only. Both the capture and detection antibodies were raised against recombinant human IL-1R1 protein.
The capture antibody is supplied unconjugated and the detection antibody is biotin-conjugated; both are provided at 0.5 mg/mL. Both antibodies are goat-derived and purified by antigen affinity chromatography.
This antibody pair is validated for use in ELISA. It is intended for the detection of human IL-1R1 in serum, plasma, and other biological fluids.
The capture antibody is formulated in PBS with 0.04% Proclin 300 and 50% glycerol at pH 7.5. The detection antibody is formulated in PBS with 0.04% Proclin 300, 1% protective protein, and 50% glycerol at pH 7.5.
Both components should be stored at -20°C for long-term storage. Freeze-thaw cycles should be avoided to maintain antibody integrity.
Orders typically arrive within 1 to 2 weeks, and often sooner depending on your location. If your timeline is critical, please contact us before ordering and we can advise on current lead times.
This product is shipped on gel ice packs to maintain integrity during transit. Priority shipping is used as standard to minimise time in transit.
A Certificate of Analysis (CoA) is provided with every order. If you do not receive one, please contact us and we will issue it promptly.