Human IL-18 R beta/IL-1 R7/CD218b protein (Recombinant) (C-hFc) (STJP020256)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human IL-18 R beta/IL-1 R7/CD218b Protein is produced by Expi293 expression system. The target protein is expressed with sequence (Phe20-Arg356) of Human IL-18 R beta fused with hFc tag at the C-terminus.
General Information
| Short Description | Recombinant-Human IL-18 R beta/IL-1 R7/CD218b-C-hFc protein was developed in hek293 cells using the region Phe20-Arg356. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | < 1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | IL18RAP |
| Gene ID | 8807 |
| Uniprot ID | I18RA_HUMAN |
| Immunogen | Recombinant Human IL-18 R beta/IL-1 R7/CD218b Protein is produced by Expi293 expression system. The target protein is expressed with sequence (Phe20-Arg356) of Human IL-18 R beta fused with hFc tag at the C-terminus. |
| Immunogen Region | Phe20-Arg356 |
| Immunogen Sequence | FNISGCSTKKLLWTYSTRSE EEFVLFCDLPEPQKSHFCHR NRLSPKQVPEHLPFMGSNDL SDVQWYQQPSNGDPLEDIRK SYPHIIQDKCTLHFLTPGVN NSGSYICRPKMIKSPYDVAC CVKMILEVKPQTNASCEYSA SHKQDLLLGSTGSISCPSLS CQSDAQSPAVTWYKNGKLLS VERSNRIVVDEVYDYHQGTY VCDYTQSDTVSSWTVRAVVQ VRTIVGDTKLKPDILDPVE |
Additional Info
| Tissue Specificity | Detected in adrenal gland, bone marrow, brain, fetal brain, fetal liver, heart, kidney, lung, liver, peripheral blood leukocytes, placenta, prostate, salivary gland, skeletal muscle, spinal cord, testis, thymus, thyroid, trachea and uterus. Strongly expressed in peripheral blood leukocytes and spleen and, to a lesser extent, in colon. Specifically coexpressed with IL18R1 in T-helper 1 (Th1)cells. |
| Post Translational Modifications | N-glycosylated. |
| Function | Within the IL18 receptor complex, does not mediate IL18-binding, but involved in IL18-dependent signal transduction, leading to NF-kappa-B and JNK activation. May play a role in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells (Probable). |
| Protein Name | Interleukin-18 Receptor Accessory ProteinIl-18 Receptor Accessory ProteinIl-18racpAccessory Protein-LikeAcplCd218 Antigen-Like Family Member BCdw218bIl-1r Accessory Protein-LikeIl-1racplInterleukin-1 Receptor 7Il-1r-7Il-1r7Interleukin-18 Receptor Accessory Protein-LikeInterleukin-18 Receptor BetaIl-18r-BetaIl-18rbetaCd Antigen Cd218b |
| Database Links | Reactome: R-HSA-9012546 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Interleukin-18 Receptor Accessory Protein proteinIl-18 Receptor Accessory Protein proteinIl-18racp proteinAccessory Protein-Like proteinAcpl proteinCd218 Antigen-Like Family Member B proteinCdw218b proteinIl-1r Accessory Protein-Like proteinIl-1racpl proteinInterleukin-1 Receptor 7 proteinIl-1r-7 proteinIl-1r7 proteinInterleukin-18 Receptor Accessory Protein-Like proteinInterleukin-18 Receptor Beta proteinIl-18r-Beta proteinIl-18rbeta proteinCd Antigen Cd218b proteinIL18RAP proteinIL1R7 protein |
Information sourced from Uniprot.org