• Human IL-18 protein (Recombinant) (No tag) (STJP000779)
  • Human IL-18 protein (Recombinant) (No tag) (STJP000779)
  • Human IL-18 protein (Recombinant) (No tag) (STJP000779)
  • Human IL-18 protein (Recombinant) (No tag) (STJP000779)
  • Human IL-18 protein (Recombinant) (No tag) (STJP000779)
  • Human IL-18 protein (Recombinant) (No tag) (STJP000779)

Human IL-18 protein (Recombinant) (No tag) (STJP000779)

SKU:
STJP000779

Current Stock:
Host: E. coli
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human IL-18-No tag protein was developed from e. coli and has a target region of No tag. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.
Immunoreactivity: Measured by its binding ability in a functional ELISA. Immobilized recombinant Human IL18 at 5 Mu g/mL (100 Mu L/well) can bind recombinant Human IL18BPa with a linear range of 0.156-1.372 Mu g/mL.
Gene Symbol: IL18
Gene ID: 3606
Uniprot ID: IL18_HUMAN
Immunogen Region: Tyr37-Asp193
Immunogen: Recombinant Human IL-18 Protein is produced by E. coli expression system. The target protein is expressed with sequence (Tyr37-Asp193) of human IL-18 (Accession #NP_001553.1).
Post Translational Modifications The pro-IL-18 precursor is processed by CASP1 or CASP4 to yield the active form.
Function Pro-inflammatory cytokine primarily involved in epithelial barrier repair, polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.
Protein Name Interleukin-18
Il-18
Iboctadekin
Interferon Gamma-Inducing Factor
Ifn-Gamma-Inducing Factor
Interleukin-1 Gamma
Il-1 Gamma
Database Links Reactome: R-HSA-448706
Reactome: R-HSA-5620971
Reactome: R-HSA-6783783
Reactome: R-HSA-6785807
Reactome: R-HSA-9012546 Q14116-2
Reactome: R-HSA-9660826
Cellular Localisation Cytoplasm
Secreted
The Precursor Is Cytosolic
In Response To Inflammasome-Activating Signals
Cleaved And Secreted
Mature Form Is Secreted And Released In The Extracellular Milieu By Passing Through The Gasdermin-D (Gsdmd) Pore
In Contrast
The Precursor Form Is Not Released
Due To The Presence Of An Acidic Region That Is Proteolytically Removed By Casp1 During Maturation
The Secretion Is Dependent On Protein Unfolding And Facilitated By The Cargo Receptor Tmed10
Alternative Protein Names Interleukin-18 protein
Il-18 protein
Iboctadekin protein
Interferon Gamma-Inducing Factor protein
Ifn-Gamma-Inducing Factor protein
Interleukin-1 Gamma protein
Il-1 Gamma protein
IL18 protein
IGIF protein
IL1F4 protein

Information sourced from Uniprot.org

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