| Short Description : | Recombinant-Human IL-17A&IL-17F-C-His protein was developed in hek293 cells using the region Gly24-Ala155. For use in research applications. |
| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 1 EU/Mu g of the protein by LAL method. |
| Immunogen: | Recombinant Human IL-17A&IL-17F Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gly24-Ala155) & (Arg31-Gln163) of Human IL-17A&IL-17F (Accession #) fused with His tag at the C-terminal. |
| Immunogen Region: | Gly24-Ala155 |
| Background | Interleukin?17A (IL?17A) , also known as CTLA?8, is a 15?20 kDa glycosylated cytokine that plays an important role in anti?microbial and chronic inflammation. The six IL?17 cytokines (IL?17A?F) are encoded by separate genes but adopt a conserved cystine knot fold.IL-17A is a ligand for IL17RA and IL17RC. The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC. Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines. |
Information sourced from Uniprot.org