Human IL-12R beta/IL12RB1 protein (Recombinant) (His-Tag) (STJP019035)

Name: Human IL-12R beta/IL12RB1 protein (Recombinant) (His-Tag) (STJP019035)
SKU: STJP019035
Availability: InStock

⇓ Datasheet ⇓ SDS Citations

SPECIFICATIONS

HostE.coli

ImmunogenHuman

STJP019035

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Short Description	Recombinant-Human IL-12R beta/IL12RB1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications	SDS-PAGE/Denatured
Host	E.coli
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Concentration	0.25 mg/mL
Formulation	Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol
Storage Instruction	For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.

Gene Symbol	IL12RB1
Gene ID	3594
Uniprot ID	I12R1_HUMAN
Accession Number	NP_005526
Immunogen	Human
Immunogen Region	1-545aa
Immunogen Sequence	MGSSHHHHHH SSGLVPRGSH MGSMEPLVTW VVPLLFLFLL SRQGAACRTS ECCFQDPPYP DADSGSASGP RDLRCYRISS DRYECSWQYE GPTAGVSHFL RCCLSSGRCC YFAAGSATRL QFSDQAGVSV LYTVTLWVES WARNQTEKSP EVTLQLYNSV KYEPPLGDIK VSKLAGQLRM EWETPDNQVG AEVQFRHRTP SSPWKLGDCG PQDDDTESCL CPLEMNVA

Function	Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Also associates with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade.
Protein Name	Interleukin-12 Receptor Subunit Beta-1 Il-12 Receptor Subunit Beta-1 Il-12r Subunit Beta-1 Il-12r-Beta-1 Il-12rb1 Il-12 Receptor Beta Component Cd Antigen Cd212
Database Links	Reactome: R-HSA-9020591 Reactome: R-HSA-9020933
Cellular Localisation	Membrane Single-Pass Type I Membrane Protein
Alternative Protein Names	Interleukin-12 Receptor Subunit Beta-1 protein Il-12 Receptor Subunit Beta-1 protein Il-12r Subunit Beta-1 protein Il-12r-Beta-1 protein Il-12rb1 protein Il-12 Receptor Beta Component protein Cd Antigen Cd212 protein IL12RB1 protein IL12R protein IL12RB protein

Information sourced from Uniprot.org