Human IL-12B (IL-12B) Antibody Pair (STJAP00714)
General Information
| Short Description | This IL-12B antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the. |
| Applications | ELISA |
| Host | Rabbit/Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal/Monoclonal |
| Clone ID | R07-6Y2/R06-2G1 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | Determined by end user |
| Formulation | 0.01M PBS, pH 7.2 |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | IL12B |
| Gene ID | 3593 |
| Uniprot ID | IL12B_HUMAN |
| Immunogen | Recombinant protein |
Additional Info
| Post Translational Modifications | Known to be C-mannosylated in the recombinant protein.it is not yet known for sure if the wild-type protein is also modified. |
| Function | Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of pro-inflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. |
| Protein Name | Interleukin-12 Subunit BetaIl-12bCytotoxic Lymphocyte Maturation Factor 40 Kda SubunitClmf P40Il-12 Subunit P40Nk Cell Stimulatory Factor Chain 2Nksf2 |
| Database Links | Reactome: R-HSA-6783783Reactome: R-HSA-6785807Reactome: R-HSA-9020591Reactome: R-HSA-9020933 |
| Cellular Localisation | Secreted |
| Alternative Antibody Pair Names | Interleukin-12 Subunit Beta antibody pairIl-12b antibody pairCytotoxic Lymphocyte Maturation Factor 40 Kda Subunit antibody pairClmf P40 antibody pairIl-12 Subunit P40 antibody pairNk Cell Stimulatory Factor Chain 2 antibody pairNksf2 antibody pairIL12B antibody pairNKSF2 antibody pair |
Information sourced from Uniprot.org
Citations
Product Review
Frequently Asked Questions
Common questions about Human IL-12B (IL-12B) Antibody Pair (STJAP00714)
This antibody pair is designed to detect human IL-12B (UniProt P29460) and has confirmed reactivity to human samples only. It is intended for in vitro research use.
Both antibodies are rabbit monoclonal IgGs supplied unconjugated at 1 mg/mL, formulated in 0.01M PBS at pH 7.2, and purified by affinity chromatography. The clone IDs are R07-6Y2 and R06-2G1 respectively.
This pair has been validated for use in ELISA. No other assay formats are listed in the product specifications.
Working concentrations are determined by the end user and are not defined in the product specifications. Titration of each antibody is recommended to establish optimal coating and detection concentrations for a given experimental setup.
Both antibodies should be stored at 4°C for short-term use. For long-term storage, they should be aliquoted and kept at -20°C. Repeated freeze/thaw cycles should be avoided to preserve activity.
Orders typically arrive within 1 to 2 weeks, and often sooner depending on your location. If your timeline is critical, please contact us before ordering and we can advise on current lead times.
This product is shipped on gel ice packs to maintain integrity during transit. Priority shipping is used as standard to minimise time in transit.
A Certificate of Analysis (CoA) is provided with every order. If you do not receive one, please contact us and we will issue it promptly.