Human IL-12 R beta 1/CD212 protein (Recombinant) (C-hFc) (STJP019901)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human IL-12 R beta 1/CD212 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Cys24-Glu540) of Human IL-12 R beta 1/CD212 (Accession #P42701-1) fused with a C-hFc tag at the C-terminus.
General Information
| Short Description | Recombinant-Human IL-12 R beta 1/CD212-C-hFc protein was developed in hek293 cells using the region Cys24-Glu540. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Supplied as 0.22 Mu m filtered solution in PBS (pH 7.4). |
| Storage Instruction | Store at-70 °C. This product is stable at ≤-70 °C for up to 1 year from the date of receipt. For optimal storage, aliquot into smaller quantities after centrifugation and store at recommended temperature. Avoid repeated freeze-thaw cycles. |
| Determination Method | < 1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | IL12RB1 |
| Gene ID | 3594 |
| Uniprot ID | I12R1_HUMAN |
| Immunogen | Recombinant Human IL-12 R beta 1/CD212 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Cys24-Glu540) of Human IL-12 R beta 1/CD212 (Accession #P42701-1) fused with a C-hFc tag at the C-terminus. |
| Immunogen Region | Cys24-Glu540 |
| Immunogen Sequence | CRTSECCFQDPPYPDADSGS ASGPRDLRCYRISSDRYECS WQYEGPTAGVSHFLRCCLSS GRCCYFAAGSATRLQFSDQA GVSVLYTVTLWVESWARNQT EKSPEVTLQLYNSVKYEPPL GDIKVSKLAGQLRMEWETPD NQVGAEVQFRHRTPSSPWKL GDCGPQDDDTESCLCPLEMN VAQEFQLRRRQLGSQGSSWS KWSSPVCVPPENPPQPQVRF SVEQLGQDGRRRLTLKEQP |
Additional Info
| Function | Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Also associates with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade. |
| Protein Name | Interleukin-12 Receptor Subunit Beta-1Il-12 Receptor Subunit Beta-1Il-12r Subunit Beta-1Il-12r-Beta-1Il-12rb1Il-12 Receptor Beta ComponentCd Antigen Cd212 |
| Database Links | Reactome: R-HSA-9020591Reactome: R-HSA-9020933 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Interleukin-12 Receptor Subunit Beta-1 proteinIl-12 Receptor Subunit Beta-1 proteinIl-12r Subunit Beta-1 proteinIl-12r-Beta-1 proteinIl-12rb1 proteinIl-12 Receptor Beta Component proteinCd Antigen Cd212 proteinIL12RB1 proteinIL12R proteinIL12RB protein |
Information sourced from Uniprot.org