Human IL-11 protein (Active Recombinant) (No tag) (STJP000825)
SPECIFICATIONS
HostE.coli
ConjugationUnconjugated
ImmunogenRecombinant Human IL-11 Protein is produced by E. coli expression system. The target protein is expressed with sequence (Pro22-Leu199) of human IL-11 (Accession #NP_000632.1) fused with an initial Met at the N-terminus.
General Information
| Short Description | Active Recombinant-Human IL-11-No tag protein was developed in e.coli using the region Pro22-Leu199. For use in research applications. |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of 20mM Tris, 150mM NaCl, pH 8.0. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity | Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. The ED50 for this effect is 1.3-5 ng/mL, corresponding to a specific activity of 2×105-7.69×105units/mg. |
| Determination Method | < 1.0 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | IL11 |
| Gene ID | 3589 |
| Uniprot ID | IL11_HUMAN |
| Immunogen | Recombinant Human IL-11 Protein is produced by E. coli expression system. The target protein is expressed with sequence (Pro22-Leu199) of human IL-11 (Accession #NP_000632.1) fused with an initial Met at the N-terminus. |
| Immunogen Region | Pro22-Leu199 |
| Immunogen Sequence | PGPPPGPPRVSPDPRAELDS TVLLTRSLLADTRQLAAQLR DKFPADGDHNLDSLPTLAMS AGALGALQLPGVLTRLRADL LSYLRHVQWLRRAGGSSLKT LEPELGTLQARLDRLLRRLQ LLMSRLALPQPPPDPPAPPL APPSSAWGGIRAAHAILGGL HLTLDWAVRGLLLLKTRL |
Additional Info
| Function | Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production. Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and IL11RA activates a signaling cascade that promotes cell proliferation. Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. The interaction with the membrane-bound IL11RA and IL6ST stimulates 'classic signaling', whereas the binding of IL11 and soluble IL11RA to IL6ST stimulates 'trans-signaling'. |
| Protein Name | Interleukin-11Il-11Adipogenesis Inhibitory FactorAgifOprelvekin |
| Database Links | Reactome: R-HSA-6788467 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Interleukin-11 proteinIl-11 proteinAdipogenesis Inhibitory Factor proteinAgif proteinOprelvekin proteinIL11 protein |
Information sourced from Uniprot.org