Human IL-11 (IL-11) Antibody Pair (STJAP00654)
General Information
| Short Description | This IL-11 antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the. |
| Applications | ELISA |
| Host | Mouse/Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal/Monoclonal |
| Clone ID | 15G6/12A12 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | ELISA 1:1000 |
| Formulation | Liquid in PBS containing 0.09% sodium azide as a preservative./Liquid in PBS containing 0.01% thimerosal as a preservative. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | IL11 |
| Gene ID | 3589 |
| Uniprot ID | IL11_HUMAN |
| Immunogen | A synthesized peptide derived from human IL-11 |
Additional Info
| Function | Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production. Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and IL11RA activates a signaling cascade that promotes cell proliferation. Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. The interaction with the membrane-bound IL11RA and IL6ST stimulates 'classic signaling', whereas the binding of IL11 and soluble IL11RA to IL6ST stimulates 'trans-signaling'. |
| Protein Name | Interleukin-11Il-11Adipogenesis Inhibitory FactorAgifOprelvekin |
| Database Links | Reactome: R-HSA-6788467 |
| Cellular Localisation | Secreted |
| Alternative Antibody Pair Names | Interleukin-11 antibody pairIl-11 antibody pairAdipogenesis Inhibitory Factor antibody pairAgif antibody pairOprelvekin antibody pairIL11 antibody pair |
Information sourced from Uniprot.org
Citations
Product Review
Frequently Asked Questions
Common questions about Human IL-11 (IL-11) Antibody Pair (STJAP00654)
This antibody pair detects human IL-11 (UniProt P20809). Reactivity has been confirmed for human samples only.
Both antibodies are mouse monoclonal IgG1 antibodies (clones 15G6 and 12A12), supplied as affinity-purified liquids at 1 mg/mL. Neither antibody carries a conjugate or tag, so secondary detection reagents will need to be selected by the researcher.
This pair has been validated for ELISA, with a recommended dilution of 1:1000 for each antibody.
One antibody is formulated in PBS containing 0.09% sodium azide, and the other is formulated in PBS containing 0.01% thimerosal. Researchers should take note of these preservatives when selecting downstream detection enzymes, as sodium azide can inhibit horseradish peroxidase activity.
Both antibodies should be stored at 4°C for short-term use. For long-term storage, aliquots should be kept at -20°C, and repeated freeze/thaw cycles should be avoided.
Both antibodies were raised in mouse using a synthesized peptide derived from human IL-11. No immunogen region details are specified in the product information.
Orders typically arrive within 1 to 2 weeks, and often sooner depending on your location. If your timeline is critical, please contact us before ordering and we can advise on current lead times.
This product is shipped on gel ice packs to maintain integrity during transit. Priority shipping is used as standard to minimise time in transit.
A Certificate of Analysis (CoA) is provided with every order. If you do not receive one, please contact us and we will issue it promptly.