Human IL-10 receptor beta (IL10RB) protein (Recombinant) (STJP000598)

Name: Human IL-10 receptor beta (IL10RB) protein (Recombinant) (STJP000598)
SKU: STJP000598
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

HostHEK293

ConjugationUnconjugated

ImmunogenDNA sequence encoding extracellular domain of human IL-10RB fused to a C-terminal polyHis tag was expressed in HEK cells. NA

STJP000598

Current Stock:

🚚 Free UK Delivery on orders over £150

Quantity:

Processing The item has been added

Enquire For Bulk Order

✓ 1-Year Performance Guarantee | SDS & Datasheet Included | Expert Tech Support | Covered by St John's Laboratory Guarantee

Short Description	Recombinant-Human IL-10 receptor beta (IL10RB)-protein was developed from hek293. For use in research applications.
Host	HEK293
Note	STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Conjugation	Unconjugated
Dilution Range	Spin the vial and reconstite in distilled water to a concentration not less than 0.1 mg/mL. This can then be diluted into other buffers.
Formulation	Lyophilised from 0.2 Mu m filtered PBS solution pH7.4.
Storage Instruction	Can be stored in working aliquots at°C-°C C for one month, or at-20°C C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. NA
Endotoxin	Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than.1 ng/µg (1EU/µg). NA
Immunoreactivity	The activity was determined by its ability to bind Human IL-28B in functional ELISA. NA

Gene Symbol	IL10RB
Gene ID	3588
Uniprot ID	I10R2_HUMAN
Immunogen	DNA sequence encoding extracellular domain of human IL-10RB fused to a C-terminal polyHis tag was expressed in HEK cells. NA
Immunogen Region	ECD
Immunogen Sequence	MAWSLGSWLG GCLLVSALGM VPPPENVRMN SVNFKNILQW ESPAFAKGNL TFTAQYLSYR IFQDKCMNTT LTECDFSSLS KYGDHTLRVR AEFADEHSDW VNITFCPVDD TIIGPPGMQV EVLADSLHMR FLAPKIENEY ETWTMKNVYN SWTYNVQYWK NGTDEKFQIT PQYDFEVLRN LEPWTTYCVQ VRGFLPDRNK AGEWSEPVCE QTTHDETVPS WMVAVILM

Function	Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state.
Protein Name	Interleukin-10 Receptor Subunit Beta Il-10 Receptor Subunit Beta Il-10r Subunit Beta Il-10rb Cytokine Receptor Class-Ii Member 4 Cytokine Receptor Family 2 Member 4 Crf2-4 Interleukin-10 Receptor Subunit 2 Il-10r Subunit 2 Il-10r2 Cd Antigen Cdw210b
Database Links	Reactome: R-HSA-449836 Reactome: R-HSA-6783783 Reactome: R-HSA-8854691
Cellular Localisation	Membrane Single-Pass Type I Membrane Protein
Alternative Protein Names	Interleukin-10 Receptor Subunit Beta protein Il-10 Receptor Subunit Beta protein Il-10r Subunit Beta protein Il-10rb protein Cytokine Receptor Class-Ii Member 4 protein Cytokine Receptor Family 2 Member 4 protein Crf2-4 protein Interleukin-10 Receptor Subunit 2 protein Il-10r Subunit 2 protein Il-10r2 protein Cd Antigen Cdw210b protein IL10RB protein CRFB4 protein D21S58 protein D21S66 protein

Information sourced from Uniprot.org