| Host: |
HEK293 |
| Note: |
STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Human IL-10 receptor beta (IL10RB)-protein was developed from hek293. For use in research applications. |
| Conjugation: |
Unconjugated |
| Formulation: |
Lyophilised from 0.2 Mu m filtered PBS solution pH7.4. |
| Dilution Range: |
Spin the vial and reconstite in distilled water to a concentration not less than 0.1 mg/mL. This can then be diluted into other buffers. |
| Storage Instruction: |
Can be stored in working aliquots at°C-°C C for one month, or at-20°C C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. NA |
| Endotoxin: |
Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than.1 ng/µg (1EU/µg). NA |
| Immunoreactivity: |
The activity was determined by its ability to bind Human IL-28B in functional ELISA. NA |
| Gene Symbol: |
IL10RB |
| Gene ID: |
3588 |
| Uniprot ID: |
I10R2_HUMAN |
| Immunogen Region: |
ECD |
| Immunogen: |
DNA sequence encoding extracellular domain of human IL-10RB fused to a C-terminal polyHis tag was expressed in HEK cells. NA |
| Immunogen Sequence: |
MAWSLGSWLG GCLLVSALGM VPPPENVRMN SVNFKNILQW ESPAFAKGNL TFTAQYLSYR IFQDKCMNTT LTECDFSSLS KYGDHTLRVR AEFADEHSDW VNITFCPVDD TIIGPPGMQV EVLADSLHMR FLAPKIENEY ETWTMKNVYN SWTYNVQYWK NGTDEKFQIT PQYDFEVLRN LEPWTTYCVQ VRGFLPDRNK AGEWSEPVCE QTTHDETVPS WMVAVILM |
| Function | Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. |
| Protein Name | Interleukin-10 Receptor Subunit BetaIl-10 Receptor Subunit BetaIl-10r Subunit BetaIl-10rbCytokine Receptor Class-Ii Member 4Cytokine Receptor Family 2 Member 4Crf2-4Interleukin-10 Receptor Subunit 2Il-10r Subunit 2Il-10r2Cd Antigen Cdw210b |
| Database Links | Reactome: R-HSA-449836Reactome: R-HSA-6783783Reactome: R-HSA-8854691 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Interleukin-10 Receptor Subunit Beta proteinIl-10 Receptor Subunit Beta proteinIl-10r Subunit Beta proteinIl-10rb proteinCytokine Receptor Class-Ii Member 4 proteinCytokine Receptor Family 2 Member 4 proteinCrf2-4 proteinInterleukin-10 Receptor Subunit 2 proteinIl-10r Subunit 2 proteinIl-10r2 proteinCd Antigen Cdw210b proteinIL10RB proteinCRFB4 proteinD21S58 proteinD21S66 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
