Human IKZF3 protein (Recombinant) (N-His) (STJP011030)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human IKZF3-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | IKZF3 |
| Gene ID | 22806 |
| Uniprot ID | IKZF3_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Glu84-Thr326 |
Additional Info
| Post Translational Modifications | Phosphorylation on tyrosine residues induced by IL2 is required for dissociation from HRAS and nuclear translocation of IKZF3 in T-cells. Phosphorylation on tyrosine residues induced by IL4 is required for dissociation from Bcl-X(L) in T-cells. |
| Function | Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner. |
| Protein Name | Zinc Finger Protein AiolosIkaros Family Zinc Finger Protein 3 |
| Database Links | |
| Cellular Localisation | NucleusCytoplasmIsoform 1: NucleusIsoform 3: NucleusIsoform 11: NucleusIsoform 14: NucleusIsoform 12: Cytoplasm |
| Alternative Protein Names | Zinc Finger Protein Aiolos proteinIkaros Family Zinc Finger Protein 3 proteinIKZF3 proteinZNFN1A3 protein |
Information sourced from Uniprot.org