Human IkB-beta protein (Recombinant) (His-Tag) (STJP017551)

Name: Human IkB-beta protein (Recombinant) (His-Tag) (STJP017551)
SKU: STJP017551
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

HostE.coli

ImmunogenHuman

STJP017551

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Short Description	Recombinant-Human IkB-beta-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications	SDS-PAGE
Host	E.coli
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Concentration	1 mg/mL
Formulation	Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 20% Glycerol, 1mM DTT
Storage Instruction	For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.

Gene Symbol	NFKBIB
Gene ID	4793
Uniprot ID	IKBB_HUMAN
Accession Number	NP_002494
Immunogen	Human
Immunogen Region	1-356aa
Immunogen Sequence	MGSSHHHHHH SSGLVPRGSH MGSHMAGVAC LGKAADADEW CDSGLGSLGP DAAAPGGPGL GAELGPGLSW APLVFGYVTE DGDTALHLAV IHQHEPFLDF LLGFSAGTEY MDLQNDLGQT ALHLAAILGE TSTVEKLYAA GAGLCVAERR GHTALHLACR VGAHACARAL LQPRPRRPRE APDTYLAQGP DRTPDTNHTP VALYPDSDLE KEEEESEEDW KLQLEAEN

Tissue Specificity	Expressed in all tissues examined.
Post Translational Modifications	Phosphorylated by RPS6KA1.followed by degradation. Interaction with NKIRAS1 and NKIRAS2 probably prevents phosphorylation.
Function	Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.
Protein Name	Nf-Kappa-B Inhibitor Beta Nf-Kappa-Bib I-Kappa-B-Beta Ikb-B Ikb-Beta Ikappabbeta Thyroid Receptor-Interacting Protein 9 Tr-Interacting Protein 9 Trip-9
Database Links	Reactome: R-HSA-1169091 Reactome: R-HSA-1810476 Reactome: R-HSA-445989 Reactome: R-HSA-933542
Cellular Localisation	Cytoplasm Nucleus
Alternative Protein Names	Nf-Kappa-B Inhibitor Beta protein Nf-Kappa-Bib protein I-Kappa-B-Beta protein Ikb-B protein Ikb-Beta protein Ikappabbeta protein Thyroid Receptor-Interacting Protein 9 protein Tr-Interacting Protein 9 protein Trip-9 protein NFKBIB protein IKBB protein TRIP9 protein

Information sourced from Uniprot.org