• Human IgG4 protein (Recombinant) (C-His) (STJP002544)

Human IgG4 protein (Recombinant) (C-His) (STJP002544)

SKU:
STJP002544

Current Stock:
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human IgG4-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: IGHG4Uniprot ID=IGHG4_HUMAN"
Immunogen Region: Glu99-Lys327
Immunogen: Recombinant Human IgG4 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Glu99-Lys327) of human IGHG4 fused with a 6×His tag at the C-terminus.
Function Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens. The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen.
Protein Name Immunoglobulin Heavy Constant Gamma 4
Ig Gamma-4 Chain C Region
Cellular Localisation Isoform 1: Secreted
Isoform 2: Cell Membrane
Single-Pass Membrane Protein
Alternative Protein Names Immunoglobulin Heavy Constant Gamma 4 protein
Ig Gamma-4 Chain C Region protein
IGHG4 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance