Human IGFBP2 (IGFBP2) Antibody Pair (STJAP00879)
General Information
| Short Description | This IGFBP2 antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the. |
| Applications | ELISA |
| Host | Rabbit/Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal/Monoclonal |
| Clone ID | R06-9F-4/R07-2C-3 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Purification |
| Dilution Range | Determined by end user |
| Formulation | 0.01M PBS, pH 7.2 |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | IGFBP2 |
| Gene ID | 3485 |
| Uniprot ID | IBP2_HUMAN |
| Immunogen | Recombinant protein |
Additional Info
| Post Translational Modifications | Cleaved by MMP9 leading to release of free IGF2 from IGFBP2-IGF2 complex, which contributes to enhance the motility and the growth of astrocytes. O-glycosylated. |
| Function | Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type specific manner. Functions coordinately with receptor protein tyrosine phosphatase beta/PTPRB and the IGF1 receptor to regulate IGF1-mediated signaling by stimulating the phosphorylation of PTEN leading to its inactivation and AKT1 activation. Plays a positive role in cell migration via interaction with integrin alpha5/ITGA5 through an RGD motif. Additionally, interaction with ITGA5/ITGB1 enhances the adhesion of endothelial progenitor cells to endothelial cells. Upon mitochondrial damage, facilitates apoptosis with ITGA5 of podocytes, and then activates the phosphorylation of focal adhesion kinase (FAK)-mediated mitochondrial injury. |
| Protein Name | Insulin-Like Growth Factor-Binding Protein 2Ibp-2Igf-Binding Protein 2Igfbp-2 |
| Database Links | Reactome: R-HSA-381426 |
| Cellular Localisation | Secreted |
| Alternative Antibody Pair Names | Insulin-Like Growth Factor-Binding Protein 2 antibody pairIbp-2 antibody pairIgf-Binding Protein 2 antibody pairIgfbp-2 antibody pairIGFBP2 antibody pairBP2 antibody pairIBP2 antibody pair |
Information sourced from Uniprot.org
Citations
Product Review
Frequently Asked Questions
Common questions about Human IGFBP2 (IGFBP2) Antibody Pair (STJAP00879)
This antibody pair is designed to detect human IGFBP2 (Insulin-like Growth Factor Binding Protein 2, UniProt P18065). Reactivity has been confirmed for human samples only.
Both antibodies in this pair are rabbit monoclonal IgGs, raised against a recombinant protein immunogen. The clone IDs are R06-9F-4 and R07-2C-3, and both are supplied unconjugated and affinity purified.
This pair has been validated for use in ELISA. It has not been validated for other assay formats based on the available product data.
Both antibodies are formulated in 0.01M PBS at pH 7.2. No additional carrier proteins, preservatives, or conjugates are included, as both components are supplied unconjugated.
Working concentrations are to be determined by the end user and should be optimized empirically for the specific experimental setup and sample type being used.
Both antibodies should be stored at 4°C for short-term use. For long-term storage, aliquot and store at -20°C. Repeated freeze/thaw cycles should be avoided to maintain antibody integrity.
Orders typically arrive within 1 to 2 weeks, and often sooner depending on your location. If your timeline is critical, please contact us before ordering and we can advise on current lead times.
This product is shipped on gel ice packs to maintain integrity during transit. Priority shipping is used as standard to minimise time in transit.
A Certificate of Analysis (CoA) is provided with every order. If you do not receive one, please contact us and we will issue it promptly.