Human IGFBP-5 (Insulin-Like Growth Factor-Binding Protein 5) Antibody Pair (STJAP00139)
General Information
| Short Description | This IGFBP-5 antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA. |
| Applications | ELISA |
| Host | Mouse/Mouse |
| Reactivity | Human |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Clonality | Monoclonal/Monoclonal |
| Conjugation | Unconjugated/Biotin |
| Concentration | 0.5 mg/mL |
| Purification | Capture Purification: Protein A.Detection Purification: Protein A. |
| Formulation | Capture Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4.Detection Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4. |
| Storage Instruction | Store at-20°C for the long term, and avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | IGFBP5 |
| Gene ID | 3488 |
| Uniprot ID | IBP5_HUMAN |
| Immunogen | Capture immunogen: Recombinant Human IGFBP-5 protein.Detection Immunogen: Recombinant Human IGFBP-5 protein. |
Additional Info
| Post Translational Modifications | Cleaved by C1S in extracellular space. |
| Function | Multifunctional protein that plays a critical role in regulating the availability of IGFs to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type specific manner. Increases the cell proliferation of osteoblasts, intestinal smooth muscle cells and neuroblastoma cells. Enhances adhesion and survival of epithelial cells but decreases adhesion of mesenchymal cells. Once secreted, acts as a major mediator of mTORC1-dependent feedback inhibition of IGF1 signaling. Also plays a role in the induction of extracellular matrix (ECM) production and deposition independently of its nuclear translocation and binding to IGFs. Acts itself as a growth factor that can act independently of IGFs to regulate bone formation. Acts as a ligand for the ROR1 receptor which triggers formation of ROR1/HER2 heterodimer to enhance CREB oncogenic signaling. |
| Protein Name | Insulin-Like Growth Factor-Binding Protein 5Ibp-5Igf-Binding Protein 5Igfbp-5 |
| Database Links | Reactome: R-HSA-381426Reactome: R-HSA-8957275 |
| Cellular Localisation | SecretedCytoplasmNucleus |
| Alternative Antibody Pair Names | Insulin-Like Growth Factor-Binding Protein 5 antibody pairIbp-5 antibody pairIgf-Binding Protein 5 antibody pairIgfbp-5 antibody pairIGFBP5 antibody pairIBP5 antibody pair |
Information sourced from Uniprot.org
Citations
Product Review
Frequently Asked Questions
Common questions about Human IGFBP-5 (Insulin-Like Growth Factor-Binding Protein 5) Antibody Pair (STJAP00139)
This antibody pair is designed to detect human IGFBP-5 (Insulin-Like Growth Factor-Binding Protein 5), corresponding to UniProt entry P24593. Reactivity is confirmed for human samples only.
The capture antibody is supplied unconjugated, while the detection antibody is biotin-conjugated. Both are mouse monoclonal antibodies purified by Protein A, supplied at 0.5 mg/mL in PBS with 0.04% Proclin 300 and 50% glycerol at pH 7.4.
This antibody pair has been validated for use in ELISA. No other assay formats are listed in the product documentation.
Both the capture and detection antibodies were raised against recombinant human IGFBP-5 protein. Both antibodies are of mouse monoclonal origin.
Both components should be stored at -20°C for long-term storage. Freeze-thaw cycles should be avoided to maintain antibody integrity.
Orders typically arrive within 1 to 2 weeks, and often sooner depending on your location. If your timeline is critical, please contact us before ordering and we can advise on current lead times.
This product is shipped on gel ice packs to maintain integrity during transit. Priority shipping is used as standard to minimise time in transit.
A Certificate of Analysis (CoA) is provided with every order. If you do not receive one, please contact us and we will issue it promptly.