Human IGFBP-4 protein (Recombinant) (C-His) (STJP000959)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human IGFBP-4 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Met1-Glu258) of human IGFBP-4 (Accession #NP_001543.2) fused with a 6×His tag at the C-terminus.
General Information
| Short Description | Recombinant-Human IGFBP-4-C-His protein was developed in hek293 cells using the region Met1-Glu258. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity | 1.Measured by its binding ability in a functional ELISA. Immobilized Human IGFBP4 at 1 Mu g/mL (100 Mu L/well) can bind Human IGF1 with a linear range of 1.95-111.32 ng/mL.|2.Measured by its binding ability in a functional ELISA. Immobilized Human IG |
| Determination Method | < 0.1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | IGFBP4 |
| Gene ID | 3487 |
| Uniprot ID | IBP4_HUMAN |
| Immunogen | Recombinant Human IGFBP-4 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Met1-Glu258) of human IGFBP-4 (Accession #NP_001543.2) fused with a 6×His tag at the C-terminus. |
| Immunogen Region | Met1-Glu258 |
| Immunogen Sequence | MLPLCLVAALLLAAGPGPSL GDEAIHCPPCSEEKLARCRP PVGCEELVREPGCGCCATCA LGLGMPCGVYTPRCGSGLRC YPPRGVEKPLHTLMHGQGVC MELAEIEAIQESLQPSDKDE GDHPNNSFSPCSAHDRRCLQ KHFAKIRDRSTSGGKMKVNG APREDARPVPQGSCQSELHR ALERLAASQSRTHEDLYIIP IPNCDRNGNFHPKQCHPALD GQRGKCWCVDRKTGVKLPG |
Additional Info
| Function | IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. |
| Protein Name | Insulin-Like Growth Factor-Binding Protein 4Ibp-4Igf-Binding Protein 4Igfbp-4 |
| Database Links | Reactome: R-HSA-381426Reactome: R-HSA-8957275 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Insulin-Like Growth Factor-Binding Protein 4 proteinIbp-4 proteinIgf-Binding Protein 4 proteinIgfbp-4 proteinIGFBP4 proteinIBP4 protein |
Information sourced from Uniprot.org