• Human IGFBP-3 protein (Active Recombinant) (C-His) (STJP001355)
  • Human IGFBP-3 protein (Active Recombinant) (C-His) (STJP001355)
  • Human IGFBP-3 protein (Active Recombinant) (C-His) (STJP001355)
  • Human IGFBP-3 protein (Active Recombinant) (C-His) (STJP001355)

Human IGFBP-3 protein (Active Recombinant) (C-His) (STJP001355)

SKU:
STJP001355

Current Stock:
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Active Recombinant-Human IGFBP-3-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Immunoreactivity: Measured by its binding ability in a functional ELISA. Immobilized Human IGFBP3 Protein at 1 Mu g/mL (100 Mu L/well) can bind IGF1 with a linear range of 0.158-23.05ng/mL.
Gene Symbol: IGFBP3
Gene ID: 3486
Uniprot ID: IBP3_HUMAN
Immunogen: Recombinant Human IGFBP-3 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gly28-Lys291) of human IGFBP3/BP-53 (Accession #NP_000589.2) fused with a 6Ă—His tag at the C-terminus.
Post Translational Modifications Phosphorylated by FAM20C in the extracellular medium.
Function IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R. Inhibits the positive effect of humanin on insulin sensitivity. Promotes testicular germ cell apoptosis.
Protein Name Insulin-Like Growth Factor-Binding Protein 3
Ibp-3
Igf-Binding Protein 3
Igfbp-3
Database Links Reactome: R-HSA-381426
Reactome: R-HSA-6803211
Reactome: R-HSA-8957275
Cellular Localisation Secreted
Alternative Protein Names Insulin-Like Growth Factor-Binding Protein 3 protein
Ibp-3 protein
Igf-Binding Protein 3 protein
Igfbp-3 protein
IGFBP3 protein
IBP3 protein

Information sourced from Uniprot.org

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