Human IGFBP-1 (Insulin-Like Growth Factor-Binding Protein 1) Antibody Pair (STJAP00130)
General Information
| Short Description | This IGFBP-1 antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA. |
| Applications | ELISA |
| Host | Mouse/Mouse |
| Reactivity | Human |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Clonality | Monoclonal/Monoclonal |
| Conjugation | Unconjugated/Biotin |
| Concentration | 0.5 mg/mL |
| Purification | Capture Purification: Protein A or G.Detection Purification: Protein A or G. |
| Formulation | Capture Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4.Detection Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4. |
| Storage Instruction | Store at-20°C for the long term, and avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | IGFBP1 |
| Gene ID | 3484 |
| Uniprot ID | IBP1_HUMAN |
| Immunogen | Capture immunogen: Recombinant Human IGFBP-1 protein.Detection Immunogen: Recombinant Human IGFBP-1 protein. |
Additional Info
| Function | Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including cell migration, proliferation, differentiation or apoptosis in a cell-type specific manner. Also plays a positive role in cell migration by interacting with integrin ITGA5:ITGB1 through its RGD motif. Mechanistically, binding to integrins leads to activation of focal adhesion kinase/PTK2 and stimulation of the mitogen-activated protein kinase (MAPK) pathway. Regulates cardiomyocyte apoptosis by suppressing HIF-1alpha/HIF1A ubiquitination and subsequent degradation. |
| Protein Name | Insulin-Like Growth Factor-Binding Protein 1Ibp-1Igf-Binding Protein 1Igfbp-1Placental Protein 12Pp12 |
| Database Links | Reactome: R-HSA-380994Reactome: R-HSA-381426Reactome: R-HSA-8957275Reactome: R-HSA-9615017 |
| Cellular Localisation | Secreted |
| Alternative Antibody Pair Names | Insulin-Like Growth Factor-Binding Protein 1 antibody pairIbp-1 antibody pairIgf-Binding Protein 1 antibody pairIgfbp-1 antibody pairPlacental Protein 12 antibody pairPp12 antibody pairIGFBP1 antibody pairIBP1 antibody pair |
Information sourced from Uniprot.org
Citations
Product Review
Frequently Asked Questions
Common questions about Human IGFBP-1 (Insulin-Like Growth Factor-Binding Protein 1) Antibody Pair (STJAP00130)
This antibody pair detects human IGFBP-1 (Insulin-Like Growth Factor-Binding Protein 1), corresponding to UniProt entry P08833. Reactivity is confirmed for human samples only.
The capture antibody is supplied unconjugated and the detection antibody is biotin-conjugated, both at 0.5 mg/mL. Each component is formulated in PBS with 0.04% Proclin 300 and 50% glycerol at pH 7.4.
This pair is validated for use in ELISA. No other assay formats are listed in the product specifications.
Both the capture and detection antibodies were raised against recombinant human IGFBP-1 protein. Both are mouse monoclonal antibodies purified by Protein A or G affinity chromatography.
Both components should be stored at -20°C for long-term storage. Repeated freeze-thaw cycles should be avoided to maintain antibody integrity.
Orders typically arrive within 1 to 2 weeks, and often sooner depending on your location. If your timeline is critical, please contact us before ordering and we can advise on current lead times.
This product is shipped on gel ice packs to maintain integrity during transit. Priority shipping is used as standard to minimise time in transit.
A Certificate of Analysis (CoA) is provided with every order. If you do not receive one, please contact us and we will issue it promptly.