Human IGF2R/CD222 protein (Recombinant) (C-His&Avi) (STJP020354)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human IGF2R/CD222 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Glu47-Met1508) of human IGF2R (Accession #NP_000867.2) fused with a His, Avi tag at the C-terminus.
General Information
| Short Description | Recombinant-Human IGF2R/CD222-C-His&Avi protein was developed in hek293 cells using the region Glu47-Met1508. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | < 1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | IGF2R |
| Gene ID | 3482 |
| Uniprot ID | MPRI_HUMAN |
| Immunogen | Recombinant Human IGF2R/CD222 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Glu47-Met1508) of human IGF2R (Accession #NP_000867.2) fused with a His, Avi tag at the C-terminus. |
| Immunogen Region | Glu47-Met1508 |
Additional Info
| Post Translational Modifications | Palmitoylated. Undergoes cysteine S-palmitoylation which promotes interaction with the retromer cargo-selective complex which mediates its retrograde trafficking to the Golgi apparatus. |
| Function | Mediates the transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex. The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation by binding DPP4. |
| Protein Name | Cation-Independent Mannose-6-Phosphate ReceptorCi Man-6-P ReceptorCi-MprM6pr300 Kda Mannose 6-Phosphate ReceptorMpr 300Insulin-Like Growth Factor 2 ReceptorInsulin-Like Growth Factor Ii ReceptorIgf-Ii ReceptorM6p/Igf2 ReceptorM6p/Igf2rCd Antigen Cd222 |
| Database Links | Reactome: R-HSA-432722Reactome: R-HSA-6798695Reactome: R-HSA-6811440Reactome: R-HSA-8856825Reactome: R-HSA-8856828 |
| Cellular Localisation | Golgi Apparatus MembraneSingle-Pass Type I Membrane ProteinEndosome MembraneMainly Localized In The Golgi At Steady State And Not Detectable In LysosomeColocalized With Dpp4 In Internalized Cytoplasmic Vesicles Adjacent To The Cell Surface |
| Alternative Protein Names | Cation-Independent Mannose-6-Phosphate Receptor proteinCi Man-6-P Receptor proteinCi-Mpr proteinM6pr protein300 Kda Mannose 6-Phosphate Receptor proteinMpr 300 proteinInsulin-Like Growth Factor 2 Receptor proteinInsulin-Like Growth Factor Ii Receptor proteinIgf-Ii Receptor proteinM6p/Igf2 Receptor proteinM6p/Igf2r proteinCd Antigen Cd222 proteinIGF2R proteinMPRI protein |
Information sourced from Uniprot.org