Human IGF2R (Cation-Independent Mannose-6-Phosphate Receptor) Antibody Pair (STJAP00232)
General Information
| Short Description | This IGF2R antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA. |
| Applications | ELISA |
| Host | Mouse/Goat |
| Reactivity | Human |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Clonality | Monoclonal/Polyclonal |
| Conjugation | Unconjugated/Biotin |
| Concentration | 0.5 mg/mL |
| Purification | Capture Purification: Protein A or G.Detection Purification: Antigen Affinity. |
| Formulation | Capture Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4.Detection Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4. |
| Storage Instruction | Store at-20°C for the long term, and avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | IGF2R |
| Gene ID | 3482 |
| Uniprot ID | MPRI_HUMAN |
| Immunogen | Capture immunogen: Recombinant Human IGF2R protein.Detection Immunogen: Recombinant Human IGF2R protein. |
Additional Info
| Function | Mediates the transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex. The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation by binding DPP4. |
| Protein Name | Cation-Independent Mannose-6-Phosphate ReceptorCi Man-6-P ReceptorCi-MprM6pr300 Kda Mannose 6-Phosphate ReceptorMpr 300Insulin-Like Growth Factor 2 ReceptorInsulin-Like Growth Factor Ii ReceptorIgf-Ii ReceptorM6p/Igf2 ReceptorM6p/Igf2rCd Antigen Cd222 |
| Database Links | Reactome: R-HSA-432722Reactome: R-HSA-6798695Reactome: R-HSA-6811440Reactome: R-HSA-8856825Reactome: R-HSA-8856828 |
| Cellular Localisation | Golgi Apparatus MembraneSingle-Pass Type I Membrane ProteinEndosome MembraneMainly Localized In The Golgi At Steady State And Not Detectable In LysosomeColocalized With Dpp4 In Internalized Cytoplasmic Vesicles Adjacent To The Cell Surface |
| Alternative Antibody Pair Names | Cation-Independent Mannose-6-Phosphate Receptor antibody pairCi Man-6-P Receptor antibody pairCi-Mpr antibody pairM6pr antibody pair300 Kda Mannose 6-Phosphate Receptor antibody pairMpr 300 antibody pairInsulin-Like Growth Factor 2 Receptor antibody pairInsulin-Like Growth Factor Ii Receptor antibody pairIgf-Ii Receptor antibody pairM6p/Igf2 Receptor antibody pairM6p/Igf2r antibody pairCd Antigen Cd222 antibody pairIGF2R antibody pairMPRI antibody pair |
Information sourced from Uniprot.org
Citations
Product Review
Frequently Asked Questions
Common questions about Human IGF2R (Cation-Independent Mannose-6-Phosphate Receptor) Antibody Pair (STJAP00232)
This antibody pair detects human IGF2R, also known as the Cation-Independent Mannose-6-Phosphate Receptor (UniProt P11717). Reactivity has been confirmed for human samples only.
The capture antibody is an unconjugated mouse monoclonal antibody and the detection antibody is a biotin-conjugated goat polyclonal antibody. Both are supplied at 0.5 mg/mL in PBS with 0.04% Proclin 300 and 50% glycerol, pH 7.4.
This antibody pair has been validated for use in ELISA. No other assay formats are specified for this product.
The capture antibody was purified by Protein A or G, and the detection antibody was purified by antigen affinity purification. Both antibodies were raised against recombinant human IGF2R protein.
Both components should be stored at -20 degrees Celsius for long-term storage. Freeze-thaw cycles should be avoided to maintain reagent integrity.
Orders typically arrive within 1 to 2 weeks, and often sooner depending on your location. If your timeline is critical, please contact us before ordering and we can advise on current lead times.
This product is shipped on gel ice packs to maintain integrity during transit. Priority shipping is used as standard to minimise time in transit.
A Certificate of Analysis (CoA) is provided with every order. If you do not receive one, please contact us and we will issue it promptly.