Human IFT57 protein (Recombinant) (N-His-SUMO & C-Strep) (STJP007421)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human IFT57-N-His-SUMO & C-Strep protein was developed from e.coli for the region N-His-SUMO & C-Strep. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | IFT57 |
| Gene ID | 55081 |
| Uniprot ID | IFT57_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ala36-Gly160 |
Additional Info
| Function | Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway. Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator.however the relevance of such function remains unclear. |
| Protein Name | Intraflagellar Transport Protein 57 HomologDermal Papilla-Derived Protein 8Estrogen-Related Receptor Beta-Like Protein 1Hip1-Interacting ProteinMhs4r2 |
| Database Links | Reactome: R-HSA-5610787Reactome: R-HSA-5620924 |
| Cellular Localisation | Cell ProjectionCiliumCytoplasmCytoskeletonCilium Basal BodyConcentrates Within The Inner Segment Of Cilia |
| Alternative Protein Names | Intraflagellar Transport Protein 57 Homolog proteinDermal Papilla-Derived Protein 8 proteinEstrogen-Related Receptor Beta-Like Protein 1 proteinHip1-Interacting Protein proteinMhs4r2 proteinIFT57 proteinDERP8 proteinESRRBL1 proteinHIPPI protein |
Information sourced from Uniprot.org