Human IFNLR1/IL-28RA protein (Recombinant-Active) (C-hFc-His) (STJP012191)
SPECIFICATIONS
HostMammalian Cells
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Active-Human IFNLR1/IL-28RA-C-hFc-His protein was developed from mammalian cells and has a target region of C-hFc-His. For use in research applications. |
| Applications | ELISA/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | <0.1 EU/Mu g of the protein by the LAL method. |
| Immunoreactivity | Measured by its binding ability in a functional ELISA. In a 100 Mu L reaction mixture containing rhIFNLR1/IL-28RA at 1 Mu g/mL and rhIL-28A dilutions at 1-1000 ng/mL, the concentration of rhIL-28A that produces 50% of the optimal binding response is |
Target Information
| Gene Symbol | IFNLR1 |
| Gene ID | 163702 |
| Uniprot ID | INLR1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Arg21-Ala228 |
Additional Info
| Post Translational Modifications | Ubiquitinated by FBXO45-containing E3 ligase leading to proteasomal degradation. |
| Function | The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. |
| Protein Name | Interferon Lambda Receptor 1Ifn-Lambda Receptor 1Ifn-Lambda-R1Cytokine Receptor Class-Ii Member 12Cytokine Receptor Family 2 Member 12Crf2-12Interleukin-28 Receptor Subunit AlphaIl-28 Receptor Subunit AlphaIl-28r-AlphaIl-28raLikely Interleukin Or Cytokine Receptor 2Licr2 |
| Database Links | Reactome: R-HSA-449836Reactome: R-HSA-8854691 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Interferon Lambda Receptor 1 proteinIfn-Lambda Receptor 1 proteinIfn-Lambda-R1 proteinCytokine Receptor Class-Ii Member 12 proteinCytokine Receptor Family 2 Member 12 proteinCrf2-12 proteinInterleukin-28 Receptor Subunit Alpha proteinIl-28 Receptor Subunit Alpha proteinIl-28r-Alpha proteinIl-28ra proteinLikely Interleukin Or Cytokine Receptor 2 proteinLicr2 proteinIFNLR1 proteinIL28RA proteinLICR2 protein |
Information sourced from Uniprot.org