• Human IFN-lambda 2/IL-28A protein (Recombinant) (C-His) (STJP001000)

Human IFN-lambda 2/IL-28A protein (Recombinant) (C-His) (STJP001000)

SKU:
STJP001000

Current Stock:
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human IFN-lambda 2/IL-28A-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.
Gene Symbol: IFNL2
Gene ID: 282616
Uniprot ID: IFNL2_HUMAN
Immunogen: Recombinant Human IFN-lambda 2/IL-28A Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Val26-Val200) of human IL-28A/IL28A (Accession #NP_742150.1) fused with a 6×His tag at the C-terminus.
Function Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.
Protein Name Interferon Lambda-2
Ifn-Lambda-2
Cytokine Zcyto20
Interleukin-28a
Il-28a
Database Links Reactome: R-HSA-8854691
Cellular Localisation Secreted
Alternative Protein Names Interferon Lambda-2 protein
Ifn-Lambda-2 protein
Cytokine Zcyto20 protein
Interleukin-28a protein
Il-28a protein
IFNL2 protein
IL28A protein
ZCYTO20 protein

Information sourced from Uniprot.org

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