Name: Human IFN-lambda 1/IL-29 protein (Recombinant) (C-His) (STJP001077)
SKU: STJP001077
Availability: InStock

Human IFN-lambda 1/IL-29 protein (Recombinant) (C-His) (STJP001077)

SKU:

STJP001077

$120.83 - $370.58

Host:	HEK293 cells
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Formulation:	Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method:	Please contact us for more information.

Gene Symbol:	IFNL1
Gene ID:	282618
Uniprot ID:	IFNL1_HUMAN
Immunogen:	Recombinant Human IFN-lambda 1/IL-29 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Gly20-Thr200) of human IL-29 (Accession #NP_742152.1) fused with a 6×His tag at the C-terminus.
Immunogen Sequence:	GPVPTSKPTTTGKGCHIGRF KSLSPQELASFKKARDALEE SLKLKNWSCSSPVFPGNWDL RLLQVRERPVALEAELALTL KVLEAAAGPALEDVLDQPLH TLHHILSQLQACIQPQPTAG PRPRGRLHHWLHRLQEAPKK ESAGCLEASVTFNLFRLLTR DLKYVADGNLCLRTSTHPES T

Function	Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.
Protein Name	Interferon Lambda-1 Ifn-Lambda-1 Cytokine Zcyto21 Interleukin-29 Il-29
Database Links	Reactome: R-HSA-449836 Reactome: R-HSA-8854691
Cellular Localisation	Secreted
Alternative Protein Names	Interferon Lambda-1 protein Ifn-Lambda-1 protein Cytokine Zcyto21 protein Interleukin-29 protein Il-29 protein IFNL1 protein IL29 protein ZCYTO21 protein

Information sourced from Uniprot.org

Model	Name	Host
STJP001000	Human IFN-lambda 2/IL-28A protein (Recombinant) (C-His) (STJP001000)	HEK293 cells
STJP002601	Human IFN-lambda 3/IL-28B protein (Recombinant) (C-His) (STJP002601)	HEK293 cells
STJP000874	Human IL-1 alpha protein (Recombinant) (C-His) (STJP000874)	HEK293 cells
STJP001424	Human IFN-alpha 2 protein (Recombinant) (C-His) (STJP001424)	HEK293 cells
STJP000785	Human IFN-alpha 1/13 (Q114A) protein (Recombinant) (C-His) (STJP000785)	E. coli
STJP000813	Human IL-16 protein (Recombinant) (C-His) (STJP000813)	E. coli
STJP001096	Human IL-4 protein (Recombinant) (C-His) (STJP001096)	HEK293 cells
STJP001120	Human IL-7 protein (Recombinant) (C-His) (STJP001120)	HEK293 cells

Human IFN-lambda 1/IL-29 protein (Recombinant) (C-His) (STJP001077)