Human IFN-gamma R2 protein (Recombinant) (C-RaFC) (STJP002854)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human IFN-gamma R2 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser28-Asp240) of human IFN-gamma R2 (Accession #NP_005525.2) fused with and a RaFc tag at the C-terminus.
General Information
| Short Description | Recombinant-Human IFN-gamma R2-C-RaFC protein was developed in hek293 cells using the region Ser28-Asp240. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | <0.1 EU/Mu g |
Target Information
| Gene Symbol | IFNGR2 |
| Gene ID | 3460 |
| Uniprot ID | INGR2_HUMAN |
| Immunogen | Recombinant Human IFN-gamma R2 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser28-Asp240) of human IFN-gamma R2 (Accession #NP_005525.2) fused with and a RaFc tag at the C-terminus. |
| Immunogen Region | Ser28-Asp240 |
| Immunogen Sequence | SQLPAPQHPKIRLYNAEQVL SWEPVALSNSTRPVVYQVQF KYTDSKWFTADIMSIGVNCT QITATECDFTAASPSAGFPM DFNVTLRLRAELGALHSAWV TMPWFQHYRNVTVGPPENIE VTPGEGSLIIRFSSPFDIAD TSTAFFCYYVHYWEKGGIQQ VKGPFRSNSISLDNLKPSRV YCLQVQAQLLWNKSNIFRVG HLSNISCYETMAD |
Additional Info
| Function | Associates with IFNGR1 to form a receptor for the cytokine interferon gamma (IFNG). Ligand binding stimulates activation of the JAK/STAT signaling pathway. Required for signal transduction in contrast to other receptor subunit responsible for ligand binding. |
| Protein Name | Interferon Gamma Receptor 2Ifn-Gamma Receptor 2Ifn-Gamma-R2Interferon Gamma Receptor Accessory Factor 1Af-1Interferon Gamma Receptor Beta-ChainIfn-Gamma-R-BetaInterferon Gamma Transducer 1 |
| Database Links | Reactome: R-HSA-877300Reactome: R-HSA-877312Reactome: R-HSA-9679191Reactome: R-HSA-9732724 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCytoplasmic Vesicle MembraneGolgi Apparatus MembraneEndoplasmic Reticulum MembraneCytoplasmHas Low Cell Surface Expression And High Cytoplasmic Expression In T CellsThe Bias Towards Cytoplasmic Expression May Be Due To Ligand-Independent Receptor Internalization And Recycling |
| Alternative Protein Names | Interferon Gamma Receptor 2 proteinIfn-Gamma Receptor 2 proteinIfn-Gamma-R2 proteinInterferon Gamma Receptor Accessory Factor 1 proteinAf-1 proteinInterferon Gamma Receptor Beta-Chain proteinIfn-Gamma-R-Beta proteinInterferon Gamma Transducer 1 proteinIFNGR2 proteinIFNGT1 protein |
Information sourced from Uniprot.org