Human IFN-alpha B2/IFNA8 protein (Recombinant) (N-His) (STJP003070)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human IFN-alpha B2/IFNA8 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser24-Glu189) of Human IFN-alpha B2/IFNA8 (Accession #NP_002161.2) fused with a His tag at the C-terminus.
General Information
| Short Description | Recombinant-Human IFN-alpha B2/IFNA8-N-His protein was developed in hek293 cells using the region Ser24-Glu189. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20Β°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity | Measured in a cellΒ cytotoxicityΒ assay using TF-1 cells. The ED50 for this effect is 0.10β0.42 ng/mL, corresponding to a specific activity of 2.38Γ106~1.0Γ107 units/mg. |
| Determination Method | <0.01 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | IFNA8 |
| Gene ID | 3445 |
| Uniprot ID | IFNA8_HUMAN |
| Immunogen | Recombinant Human IFN-alpha B2/IFNA8 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser24-Glu189) of Human IFN-alpha B2/IFNA8 (Accession #NP_002161.2) fused with a His tag at the C-terminus. |
| Immunogen Region | Ser24-Glu189 |
| Immunogen Sequence | CCHPRLSLHRPALEDLLLGS EANLTCTLTGLRDASGVTFT WTPSSGKSAVQGPPERDLCG CYSVSSVLPGCAEPWNHGKT FTCTAAYPESKTPLTATLSK SGNTFRPEVHLLPPPSEELA LNELVTLTCLARGFSPKDVL VRWLQGSQELPREKYLTWAS RQEPSQGTTTFAVTSILRVA AEDWKKGDTFSCMVGHEALP LAFTQKTIDRLADWQMPPPY VVLDLPQETLEE |
Additional Info
| Function | Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. |
| Protein Name | Interferon Alpha-8Ifn-Alpha-8Interferon Alpha-BLeif BInterferon Alpha-B2 |
| Database Links | Reactome: R-HSA-909733Reactome: R-HSA-912694Reactome: R-HSA-933541Reactome: R-HSA-9705671Reactome: R-HSA-983231Reactome: R-HSA-9833109 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Interferon Alpha-8 proteinIfn-Alpha-8 proteinInterferon Alpha-B proteinLeif B proteinInterferon Alpha-B2 proteinIFNA8 protein |
Information sourced from Uniprot.org