Human IFN-alpha 4 protein (Recombinant) (N-hFc) (STJP002989)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Recombinant Human IFN-alpha 4 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Cys24-Asp189) of Human IFN-alpha 4 (Accession #NP_066546.1) fused with a His tag at the C-terminus.
General Information
| Short Description | Recombinant-Human IFN-alpha 4-N-hFc protein was developed in hek293 cells using the region Cys24-Asp189. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from 0.22 Mu m filtered solution in PBS (pH 7.4). Normally 8% Trehalose is added as protectant before lyophilisation. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity | Measured in a cell cytotoxicity assay using TF-1 cells. The ED50 for this effect is 0.26‑1.02 ng/mL, corresponding to a specific activity of 9.80×105~3.85×106 units/mg. |
| Determination Method | < 0.1 EU/Mu g of the protein by LAL method |
Target Information
| Gene Symbol | IFNA4 |
| Gene ID | 3441 |
| Uniprot ID | IFNA4_HUMAN |
| Immunogen | Recombinant Recombinant Human IFN-alpha 4 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Cys24-Asp189) of Human IFN-alpha 4 (Accession #NP_066546.1) fused with a His tag at the C-terminus. |
| Immunogen Region | Cys24-Asp189 |
| Immunogen Sequence | VSITKCSSDMNGYCLHGQCI YLVDMSQNYCRCEVGYTGVR CEHFFL |
Additional Info
| Function | Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. |
| Protein Name | Interferon Alpha-4Ifn-Alpha-4Interferon Alpha-4bInterferon Alpha-76Interferon Alpha-M1 |
| Database Links | Reactome: R-HSA-909733Reactome: R-HSA-912694Reactome: R-HSA-933541Reactome: R-HSA-9705671Reactome: R-HSA-983231Reactome: R-HSA-9833109 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Interferon Alpha-4 proteinIfn-Alpha-4 proteinInterferon Alpha-4b proteinInterferon Alpha-76 proteinInterferon Alpha-M1 proteinIFNA4 protein |
Information sourced from Uniprot.org