Human IER3 protein (Recombinant) (N-GST & C-His) (STJP016309)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human IER3-N-GST & C-His protein was developed from e.coli for the region N-GST & C-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | Please contact us for further information. |
Target Information
| Gene Symbol | IER3 |
| Gene ID | 8870 |
| Uniprot ID | IEX1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met100-Phe156 |
Additional Info
| Function | May play a role in the ERK signaling pathway by inhibiting the dephosphorylation of ERK by phosphatase PP2A-PPP2R5C holoenzyme. Also acts as an ERK downstream effector mediating survival. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. |
| Protein Name | Radiation-Inducible Immediate-Early Gene Iex-1Differentiation-Dependent Gene 2 ProteinProtein Dif-2Immediate Early Protein Gly96Immediate Early Response 3 ProteinPacap-Responsive Gene 1 ProteinProtein Prg1 |
| Database Links | Reactome: R-HSA-6811558 |
| Cellular Localisation | MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Protein Names | Radiation-Inducible Immediate-Early Gene Iex-1 proteinDifferentiation-Dependent Gene 2 Protein proteinProtein Dif-2 proteinImmediate Early Protein Gly96 proteinImmediate Early Response 3 Protein proteinPacap-Responsive Gene 1 Protein proteinProtein Prg1 proteinIER3 proteinDIF2 proteinIEX1 proteinPRG1 protein |
Information sourced from Uniprot.org